Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production.
Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production.
复制标题
心脏对慢性缺氧的适应通过增加一氧化氮的产生来增加对随后的缺血的耐受性。
DOI：
10.1007/978-1-4615-4863-8_25
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发表时间：
1998
影响因子：
--
通讯作者：
PritchardJr,KA
中科院分区：
文献类型：
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作者：
Baker,JE;Holman,P;Kalyanaraman,B;PritchardJr,KA
每年有超过25,000名儿童接受先天性心脏缺陷矫正手术。外科技术的进步使几乎所有先天性心脏缺陷的矫正成为可能。手术时机至关重要，早期手术有利于促进更正常的发育。例如，法洛四联症的修复现在一般建议在出生后的前6至12个月进行，而常规修复现在被提倡在出生后的第一个月进行。1 - 7许多在出生后第一年接受心脏手术的儿童表现出不同程度的紫绀型心脏病，心肌长期灌注低氧血液。了解青紫型先天性心脏病改变心肌的机制以及这种改变如何影响缺血期间的保护机制，可能为开发限制手术期间心肌损伤的治疗方法提供见解。
Each year, in excess of 25,000 children undergo corrective surgery for cardiac birth defects. Advances in surgical techniques have made possible the correction of nearly all congenital cardiac defects. Timing of surgery is critically important, with early surgery desirable to promote more normal development. For example, repair of tetralogy of Fallot is now generally recommended in the first 6 to 12 months of life, and routine repair is now being advocated in the first month of life.1–7Many children undergoing cardiac surgery in the first year of life exhibit varying degrees of cyanotic heart disease where the myocardium is chronically perfused with hypoxic blood. Understanding the mechanisms by which cyanotic congenital heart disease modifies the myocardium and how that modification impacts on protective mechanics during ischemia may provide insight into developing treatments for limiting myocardial damage during surgery.