Biologic features (inflammation and neoangiogenesis) and atherosclerotic risk factors in carotid plaques and calcified aortic valve stenosis: Two different sites of the same disease?
Biologic features (inflammation and neoangiogenesis) and atherosclerotic risk factors in carotid plaques and calcified aortic valve stenosis: Two different sites of the same disease?
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DOI：
10.1309/w75nte5qbc9dxe03
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发表时间：
2006-10-01
影响因子：
3.5
通讯作者：
Tanganelli, Piero
中科院分区：
文献类型：
--
作者：
Mazzone, Annamaria;Epistolato, Maria Carmela;Tanganelli, Piero
新血管生成和炎症在动脉粥样硬化中起关键作用。观察结果支持这样的假设：钙化主动脉瓣狭窄是一种炎症过程，在组织特征和危险因素上与动脉粥样硬化相似。我们研究了两组病例：47例受血流动力学动脉粥样硬化斑块影响（1组），35例受严重钙化主动脉瓣狭窄影响（2组）。我们比较了两组动脉粥样硬化的危险因素、形态学特征和免疫组织化学表型。在两组中，男性、吸烟者和高血压患者占多数，组织学分析显示t淋巴细胞浸润、新生血管生成、钙和硬化症评分升高。两种病变均有粘附分子表达。细胞间粘附分子I的表达与炎症浸润相关（1组，P = 0.0007； 2组，P = 0.06）。新生血管生成也与炎症浸润相关（1组，P = 0.035； 2组，P = 0.045）。在瓣膜中，新血管生成与钙相关（P = 0.048）。颈动脉斑块和钙化瓣膜狭窄显示慢性炎症过程的共同危险因素和生物学标志。炎症和新生血管生成在斑块演变和主动脉瓣狭窄的进展中起着至关重要的作用。
Neoangiogenesis and inflammation have a pivotal role in atherosclerosis. Observations support the hypothesis that calcified aortic valve stenosis is an inflammatory process, similar to atherosclerosis in tissue features and risk factors. We studied 2 groups of cases: 47 were affected by hemodynamic atherosclerotic carotid plaque (group 1) and 35 by severe calcified aortic valve stenosis (group 2). We compared the groups for atherosclerosis risk factors, morphologic features, and immunohistochemical phenotypes.In both groups, men, smokers, and hypertensive subjects prevailed, and histologic analysis showed an elevated score for T-lymphocyte infiltrates, neoangiogenesis, calcium, and sclerosis. Adhesion molecule expression was present in both lesions. Expression of intercellular adhesion molecule I correlated with inflammatory infiltrates (group 1, P = .0007; group 2, P = .06). Neoangiogenesis also correlated with inflammatory infiltrates (group 1, P = .035; group 2, P = .045). In valves, neoangiogenesis correlated with calcium (P = .048). Carotid plaque and calcified valve stenosis showed common risk factors and biologic hallmarks of a chronic inflammatory process. Inflammation and neoangiogenesis have a crucial role in plaque evolution and in the progression of aortic valve stenosis.