PET imaging of prostate cancer with F-18-Al-NODA-MATBBN
PET imaging of prostate cancer with F-18-Al-NODA-MATBBN
复制标题
使用 18F-Al-NODA-MATBBN 对前列腺癌进行 PET 成像
DOI：
10.1007/s10967-015-4577-4
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发表时间：
2016
影响因子：
1.6
通讯作者：
Yang Min
中科院分区：
文献类型：
--
作者：
Chen Fei;Zhu Bao;Pan Donghui;Xu Yuping;Lin Xiufeng;Yang Runlin;Wang Lizhen;Yang Min
通过与GRPR靶向肽MATBBN的偶联，探索了新型双功能螯合剂p-SCN-NODA的应用。p-SCN-NODA可使标记率提高到68.3 ± 1.8%。18F-Al-NODA-MATBBN可在25 min内生成，放射化学纯度大于98%。在注射后30分钟，18F-Al-NODA-MATBBN的肿瘤摄取为3.23 ± 0.23% ID/g。生物分布研究表明，18F-Al-NODA-MATBBN主要通过肾脏排泄。GRPR结合特异性还通过在注射后1小时与过量未标记的MATBBN肽共注射后18F-Al-NODA-MATBBN的肿瘤摄取减少来证明。提示18F-Al-NODA-MATBBN可能是一种潜在的前列腺癌PET示踪剂候选物。
We explored the application of new bifunctional chelating agent p-SCN-NODA by conjugating to GRPR targeting peptide, MATBBN. p-SCN-NODA can increase the labeling yield to 68.3 ± 1.8 %. 18F-Al-NODA-MATBBN can be produced within 25 min with a radiochemical purity of more than 98 %. At 30 min post-injection, the tumor uptake for 18F-Al-NODA-MATBBN was 3.23 ± 0.23 % ID/g. Biodistribution studies revealed that 18F-Al-NODA-MATBBN was excreted mainly through the kidneys. GRPR-binding specificity was also demonstrated by reduced tumor uptake of 18F-Al-NODA-MATBBN after co-injection with excess unlabeled MATBBN peptide at 1 h post-injection. It suggests that 18F-Al-NODA-MATBBN may be a potential PET tracer candidate for monitoring prostate cancer.