Evaluation of micronucleus induction in a Chilean population environmentally exposed to arsenic
Evaluation of micronucleus induction in a Chilean population environmentally exposed to arsenic
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DOI：
10.1016/j.mrgentox.2004.07.008
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发表时间：
2004-11-14
影响因子：
1.9
通讯作者：
Marcos, R
中科院分区：
文献类型：
--
作者：
Martínez, V;Creus, A;Marcos, R
在本研究中，我们已经评估了环境暴露于地下饮用水中的砷是否会导致外周血淋巴细胞微核（MN）频率的显着增加。因此，本次调查使用了来自安托法加斯塔地区（智利北部）的106名个体以及来自孔塞普西翁地区的111名个体。在安托法加斯塔地区，经测量，饮用水中的砷含量高达0.750毫克/升。在孔塞普西翁，位于南部约2500公里处，被用作参考区，自来水中的砷含量低至0.002毫克/升。指甲中砷的总含量作为个体暴露的生物标志物。本研究中获得的细胞遗传学结果表明，暴露组中双核微核细胞（BNMN）的总体频率高于参考组，差异具有统计学显著性。此外，暴露组和参照组之间的促分裂阻滞增殖指数（CBPI）无差异。未观察到BNMN与水中砷含量或指甲中砷含量之间的关联。另一方面，当暴露组根据他们的Atacame（n）在波浪线$o上或高加索种族划分时，没有观察到他们之间的显著差异。此外，正如在其他人类生物监测研究中通常发现的那样，性别和年龄是调节暴露人群和参考人群中MN频率的因素。(C)2004 Elsevier B. V.保留所有权利。
In the present study we have evaluated whether or not environmental exposure to arsenic in ground drinking-water results in a significant increase in the frequency of micronuclei (MN) in peripheral blood lymphocytes. Thus, 106 individuals from the Antofagasta region (North Chile), together with 111 individuals from the area of Concepcion, were used in this investigation. In the Antofagasta area, arsenic levels in drinking-water as high as 0.750 mg/L were measured. In Concepcion, located about 2500 km towards the south and used as reference area, arsenic levels in tap water were as low as 0.002 mg/L. The total content of arsenic in fingernails was determined as a biomarker of individual exposure. The cytogenetic results obtained in this study indicate that in the exposed group the overall frequency of binucleated micronucleated cells (BNMN) is higher than in the reference group, the difference being statistically significant. In addition, no differences were found between the exposed and the reference groups, regarding the cytokinesis-block proliferation index (CBPI). No association was observed between BNMN and arsenic content in water or arsenic in fingernails. On the other hand, when the exposed group was divided according to their Atacame (n) over tilde $o or Caucasian ethnicity, no significant differences were observed between them. In addition, as usually found in other human biomonitoring studies, sex and age are factors that modulate the frequency of MN in both exposed and reference populations. (C) 2004 Elsevier B.V. All rights reserved.