Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults - A prospective study of parents and offspring
Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults - A prospective study of parents and offspring
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DOI：
10.1001/jama.291.18.2204
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发表时间：
2004-05-12
影响因子：
120.7
通讯作者：
O'Donnell, CJ
中科院分区：
文献类型：
--
作者：
Lloyd-Jones, DM;Nam, BH;O'Donnell, CJ
背景：父母的心血管疾病是否会增加独立于其他危险因素的风险仍然存在争议。以前的研究依赖于子女的报告，没有完全验证父母的事件。目的确定父母心血管疾病预测子女事件是否独立于传统的危险因素，使用针对父母和子女的前瞻性设计，并使用统一的标准来验证事件。设计初始队列研究。设置Framingham心脏研究，这是一项基于美国人群的流行病学队列研究，始于1948年，子女队列建立于1971年。参与者所有弗雷明翰子女研究参与者(年龄大于或等于30岁)和原始Framingham队列中的父母双方都没有心血管疾病。主要结果指标我们检查了父母心血管疾病与子女心血管疾病8年风险的关联结果在2302名男性和女性(平均年龄44岁)中，164名男性和79名女性在随访期间发生了心血管事件。与没有父母心血管疾病的参与者相比，父母中至少有一人患有过早心血管疾病(发病年龄)的参与者
Context Whether parental cardiovascular disease confers increased risk independent of other risk factors remains controversial. Prior studies relied on offspring report, without complete validation of parental events.Objective To determine whether parental cardiovascular disease predicts offspring events independent of traditional risk factors, using a prospective design for both parents and offspring, and uniform criteria to validate events.Design Inception cohort study.Setting Framingham Heart Study, a US population-based epidemiologic cohort begun in 1948 with the offspring cohort established in 1971.Participants All Framingham Offspring Study participants (aged greater than or equal to30 years) who were free of cardiovascular disease and both parents in the original Framingham cohort.Main Outcome Measures We examined the association of parental cardiovascular disease with 8-year risk of offspring cardiovascular disease, using pooled logistic regression.Results Among 2302 men and women (mean age, 44 years), 164 men and 79 women had cardiovascular events during follow-up. Compared with participants with no parental cardiovascular disease, those with at least 1 parent with premature cardiovascular disease (onset age