Papillary adenoma of the stomach. Pathologic and immunohistochemical study.
Papillary adenoma of the stomach. Pathologic and immunohistochemical study.
复制标题
胃乳头状腺瘤。
DOI：
--
复制
发表时间：
1989
影响因子：
4.6
通讯作者：
E. Tahara
中科院分区：
文献类型：
--
作者：
H. Ito;H. Yokozaki;M. Ito;E. Tahara
本文报告13例胃乳头状腺瘤，其中乳头状腺瘤8例，乳头管状腺瘤5例。除1例腺瘤外，均位于胃窦，呈圆顶状或带蒂状。组织学上，腺瘤细胞表现为不同程度的坏死，7个病灶为局灶性腺癌。乳头部杯状细胞明显少于管状部。溶菌酶在大多数乳头状腺瘤细胞的核上区，而它集中在潘氏颗粒在管状腺瘤细胞。癌胚抗原、分泌成分和糖类抗原CA 19-9在乳头状腺瘤和管状腺瘤中的分布和频率无差异。内分泌细胞的缺乏也是胃乳头状腺瘤的特征。不同的表型表达可能反映了乳头状腺瘤和管状腺瘤组织发生的差异。
A total of 13 gastric papillary adenomas composed of 8 papillary and 5 papillotubular adenomas were examined pathologically and immunohistochemically. They showed a dome-like or pedunculated appearance and were located at the antrum, except for one adenoma. Histologically, the adenoma cells showed atypia in varying degree and focal adenocarcinoma was noted in seven lesions. The number of goblet cells was apparently smaller in the papillary than in the tubular portion. Lysozyme was present at the supranuclear region in most papillary adenoma cells, whereas it was concentrated in Paneth's granules in tubular adenoma cells. No difference was found in the distribution and frequency of carcinoembryonic antigen, secretory component, and carbohydrate antigen CA 19-9 between papillary and tubular adenomas. Paucity of endocrine cells also characterized gastric papillary adenoma. Different phenotypic expressions might reflect the difference in histogenesis between papillary adenoma and tubular adenoma.