Serum carotenoid and retinol levels in African-Caribbean Tobagonian men with high prostate cancer risk in comparison with African-American men.
Serum carotenoid and retinol levels in African-Caribbean Tobagonian men with high prostate cancer risk in comparison with African-American men.
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与非裔美国男性相比，前列腺癌风险较高的非洲裔加勒比多巴哥尼亚男性的血清类胡萝卜素和视黄醇水平。
DOI：
10.1017/s0007114517000873
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Patrick,AlanL
中科院分区：
文献类型：
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作者：
McDonald,AliciaC;Bunker,ClareannH;Raman,Jay;Richie,John;Patrick,AlanL
众所周知，黑人男性患前列腺癌(PC)的风险更高。与PC有关的类胡萝卜素和视黄醇尚未在不同的高危黑人人群中进行比较。我们检测了无前列腺癌风险的非洲加勒比(AC)托巴戈尼亚男性(高级别前列腺上皮内瘤变、不典型病灶或反复异常的PC筛查)和血清前列腺特异性抗原(PSA)水平升高(≥4 ng/ml)的非裔美国人(AA)的血清类胡萝卜素和视黄醇水平。2003年参加番茄红素临床试验的AC男性和参加2001-2006年国家健康和营养调查的AA男性进行了比较。用等度高效液相色谱法分析血清标本中类胡萝卜素(β-胡萝卜素、α-胡萝卜素、β-隐黄质、叶黄素/玉米黄质和番茄红素)和视黄醇水平。采用分位数回归分析了血清类胡萝卜素和视黄醇水平与黑人种族、总体和血清PSA升高的男性之间的关系。包括69名AC男性和65名AA男性，年龄在41-79岁之间。在调整了年龄、体重指数、吸烟、文化程度和高血压等因素后，AC组的血清番茄红素和视黄醇水平低于AA组，而α-和β-胡萝卜素和叶黄素/玉米黄质水平高于AA组(P<0.05)。在PSA升高的男性中，血清视黄醇不再与种族有统计学意义(P=0.06)。可能的差异可能归因于饮食摄入量、遗传和/或影响这些微量营养素的生物利用率的因素。有必要进行前瞻性研究，调查AC患者和AA患者在微量营养素方面的差异是否会影响患PC的风险。
Black men are known to have a higher risk for prostate cancer (PC). Carotenoids and retinol, linked to PC, have not been compared in different black populations at risk. We examined serum carotenoid and retinol levels between PC-free African-Caribbean (AC) Tobagonian men with a high PC risk (high-grade prostatic intraepithelial neoplasia, atypical foci or repeated abnormal PC screenings) and African-American (AA) men with elevated serum prostate-specific antigen (PSA) levels (≥4 ng/ml). AC men who participated in the 2003 lycopene clinical trial and AA men who participated in the 2001–2006 National Health and Nutrition Examination Survey were compared. Serum specimens were analysed for carotenoid (β-carotene, α-carotene, β-cryptoxanthin, lutein/zeaxanthin and lycopene) and retinol levels by isocratic HPLC. Quantile regression was used to examine the association between serum carotenoid and retinol levels and black ethnicity, overall and among men with elevated serum PSA. There were sixty-nine AC men and sixty-five AA men, aged 41–79 years, included. AC men were associated with lower serum lycopene and retinol levels, and higher serum α- and β-carotenes and lutein/zeaxanthin levels compared with AA men, after adjusting for age, BMI, ever smoked cigarettes, education and hypertension (P≤0·03). Among men with elevated PSA, serum retinol was no longer statistically significant with ethnicity (P=0·06). Possible differences may be attributed to dietary intake, genetics and/or factors that influence bioavailability of these micronutrients. Prospective studies are warranted that investigate whether these differences in micronutrients between AC Tobagonian and AA men influence PC risk.