Association of vascular fluoride uptake with vascular calcification and coronary artery disease
Association of vascular fluoride uptake with vascular calcification and coronary artery disease
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DOI：
10.1097/mnm.0b013e32834c187e
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发表时间：
2012-01-01
影响因子：
1.5
通讯作者：
Dadparvar, Simin
中科院分区：
文献类型：
--
作者：
Li, Yuxin;Berenji, Gholam R.;Dadparvar, Simin
目的 氟化物正电子发射断层扫描/计算机断层扫描 (PET/CT) 扫描用于动脉粥样硬化成像的可行性尚未得到充分证实。本研究的目的是评估包括冠状动脉在内的各种主要动脉血管钙化的氟化物摄取情况。方法回顾性分析2009年至2010年在我院接受全身钠[F-18]氟化物PET/CT检查的61例患者的影像学资料和心血管病史。通过目视评估和标准化摄取值分析包括冠状动脉在内的主要动脉的氟化物摄取和钙化情况。结果 54 名患者 (96%) 的 361 个部位发现血管壁吸收氟化物，而 49 名患者 (88%) 的 317 个部位观察到钙化。除腹主动脉外，大多数动脉壁中氟化物吸收与钙化之间存在显着相关性。 28 名 (46%) 患者的冠状动脉吸收了氟化物，34 名 (56%) 患者观察到冠状动脉钙化。心血管事件史与冠状动脉氟化物摄取之间存在显着相关性。发生心血管事件的患者冠状动脉氟摄取值显着高于未发生心血管事件的患者。结论[F-18]氟化钠PET/CT可能有助于评估包括冠状动脉在内的主要动脉的粥样硬化过程。冠状动脉中氟化物吸收的增加可能与心血管风险的增加有关。 Nucl Med Commun 33:14-20 (C) 2011 Wolters Kluwer Health 垂直条 Lippincott Williams & Wilkins。
Objective The feasibility of a fluoride positron emission tomography/computed tomography (PET/CT) scan for imaging atherosclerosis has not been well documented. The purpose of this study was to assess fluoride uptake of vascular calcification in various major arteries, including coronary arteries.Methods We retrospectively reviewed the imaging data and cardiovascular history of 61 patients who received whole-body sodium [F-18] fluoride PET/CT studies at our institution from 2009 to 2010. Fluoride uptake and calcification in major arteries, including coronary arteries, were analyzed by both visual assessment and standardized uptake value measurement.Results Fluoride uptake in vascular walls was demonstrated in 361 sites of 54 (96%) patients, whereas calcification was observed in 317 sites of 49 (88%) patients. Significant correlation between fluoride uptake and calcification was observed in most of the arterial walls, except in those of the abdominal aorta. Fluoride uptake in coronary arteries was demonstrated in 28 (46%) patients and coronary calcifications were observed in 34 (56%) patients. There was significant correlation between history of cardiovascular events and presence of fluoride uptake in coronary arteries. The coronary fluoride uptake value in patients with cardiovascular events was significantly higher than in patients without cardiovascular events.Conclusion sodium [F-18] fluoride PET/CT might be useful in the evaluation of the atherosclerotic process in major arteries, including coronary arteries. An increased fluoride uptake in coronary arteries may be associated with an increased cardiovascular risk. Nucl Med Commun 33:14-20 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.