Reduced tetanus antibody titers in overweight children
Reduced tetanus antibody titers in overweight children
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DOI：
10.1080/08916930600597326
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发表时间：
2006-03-01
期刊：
影响因子：
3.5
通讯作者：
Cooper, DM
中科院分区：
文献类型：
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作者：
Eliakim, A;Swindt, C;Cooper, DM
营养不足会损害免疫反应，但人们对营养过剩（如肥胖）对疫苗反应的影响知之甚少。我们测量了15名超重儿童（BMI > 85年龄校正百分位数）和15名年龄匹配的正常体重对照儿童的儿童超重状态对炎症介质、循环免疫球蛋白和破伤风抗体的影响。通过渐进式斜坡式运动试验测量体能。用DXA测定瘦体重（LBM）和脂肪量。采用肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-1 β（IL-1 β）和白细胞介素-1受体拮抗剂（IL-1 ra）评估炎症状态;采用循环免疫球蛋白（IgM、伊加、IgG和IgG亚类）和破伤风特异性IgG滴度评估体液免疫。超重儿童LBM和脂肪量百分比较高，与体重标准化的峰值VO 2较低。IL-6在肥胖儿童中显著更高（超重和正常体重儿童中分别为2.6 +/-0.3vs.1.3 +/-0.3pg/ml; p < 0.05）。各组间TNF-α、IL-1 β和IL-1 ra无显著差异。各组间免疫球蛋白水平（IgM、伊加、IgG和IgG亚类）无显著差异。与正常体重对照相比，超重儿童中的抗破伤风IgG抗体显著较低（超重儿童和正常体重儿童中分别为2.4 +/-0.6vs.4.2 +/-0.5IU/ml; p < 0.05）。肥胖儿童和青少年对破伤风特异性抗体应答的降低可能是由于机械因素，如相对接种剂量较低，或由于脂肪组织增加导致注射部位吸收减少，或由于IL-6水平较高表达的慢性低度炎症导致免疫应答降低。
Under-nutrition impairs immune responses, but far less is known about the impact of over-nutrition, such as obesity, on the response to vaccines. We measured the effect of childhood overweight status on inflammatory mediators, circulating immunoglobulins and tetanus antibodies in fifteen overweight children (BMI > 85 age-adjusted percentile) and 15 age-matched normal weight controls. Fitness was measured by a progressive ramp type exercise test. Lean body mass ( LBM) and fat mass were determined by DXA. Tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and interleukin-1 receptor antagonist (IL-1ra) were used to assess the inflammatory status; and circulating immunoglobulins (IgM, IgA, IgG and IgG subclasses) and specific IgG titer to tetanus were used to assess humoral immunity. Overweight children had higher LBM and percent fat mass, and lower peak VO2 normalized to body weight. IL-6 was significantly higher in the obese children (2.6 +/- 0.3 vs. 1.3 +/- 0.3 pg/ml, in overweight and normal weight children, respectively; p < 0.05). No significant differences were found in TNF-a, IL-1 beta and IL-1ra between the groups. No significant differences were found in immunoglobulin levels (IgM, IgA, IgG and IgG subclasses) between the groups. Anti- tetanus IgG antibodies were significantly lower in the overweight children compared to normal weight controls (2.4 +/- 0.6 vs. 4.2 +/- 0.5 IU/ml, in overweight and normal weight children, respectively; p < 0.05). The reduced specific antibody response to tetanus in obese children and adolescent might be due to mechanical factors such as lower relative vaccination dose, or reduced absorption from the injection site due to increased adipose tissue, or related to reduce immune response due to the chronic low grade inflammation expressed by the higher levels of IL-6.