Ten years after the first Helicobacter pylori genome:: comparative and functional genomics provide new insights in the variability and adaptability of a persistent pathogen
Ten years after the first Helicobacter pylori genome:: comparative and functional genomics provide new insights in the variability and adaptability of a persistent pathogen
复制标题
DOI：
10.1111/j.1574-695x.2007.00244.x
复制
发表时间：
2007-07-01
影响因子：
--
通讯作者：
Bereswill, Stefan
中科院分区：
文献类型：
--
作者：
de Reuse, Hilde;Bereswill, Stefan
在这篇综述中，我们总结了基因组方法如何有助于了解最近发现的病原体幽门螺杆菌的生物学。比较基因组学为H.幽门螺杆菌惊人的遗传多样性，并对其进化历史产生了令人兴奋的假设。转录组学研究为H.幽门螺杆菌胃适应是其毒力的核心。
In this review, we summarize how genomic approaches contributed to the understanding of the biology of the recently discovered pathogen Helicobacter pylori. Comparative genomics provided new insights into H. pylori's spectacular genetic diversity and generated exiting hypotheses on its evolutionary history. Transcriptomic studies provided original information on the mechanisms of H. pylori gastric adaptation that are central to its virulence.