Avian β-defensins expression for the innate immune system in hen reproductive organs
Avian β-defensins expression for the innate immune system in hen reproductive organs
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DOI：
10.3382/ps/peu021
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发表时间：
2015-04-01
期刊：
影响因子：
4.4
通讯作者：
Yoshimura, Yukinori
中科院分区：
文献类型：
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作者：
Yoshimura, Yukinori
禽β-防御素（AvBD）攻击多种微生物，并且可能具有保护组织免受不可预见的病原微生物感染的功效。本文介绍了鸡生殖器官先天免疫系统中AvBD的表达机制。卵巢和输卵管都表达Toll样受体（TLR），其识别微生物相关的分子模式，并表达和产生AvBDs mRNA和肽，其是抗微生物肽。TLR与其配体的相互作用上调AvBD和促炎细胞因子的表达，并且促炎细胞因子也诱导AvBD的表达。预计合成的AvBD会杀死微生物。然而，增强先天免疫功能的策略尚未建立。繁殖具有更高的合成抗微生物肽以响应病原体的能力的鸟类可能是这样的策略之一。由于卵巢和输卵管是受内分泌系统调节的独特器官，因此考虑促性腺激素和性腺激素的作用对于增强局部防御功能也可能很重要。有关病原体识别和AvBD合成机制的生理信息对于增强生殖器官的免疫防御功能至关重要。
Avian beta-defensins (AvBDs) attack various microorganisms and may have efficacy to protect tissues from infection by unforeseen pathogenic microbes. This article describes the mechanism by which AvBDs are expressed in the innate immune system in hen reproductive organs. Both ovary and oviduct express Toll-like receptors (TLRs), which recognize microbe-associated molecular patterns, and express and produce AvBDs mRNA and peptides, which are antimicrobial peptides. The interaction of TLRs with their ligands upregulates the expression of AvBDs and proinflammatory cytokines, and proinflammatory cytokines also induce expression of AvBDs. The synthesized AvBDs are predicted to kill the microbes. However, strategies to enhance innate immune functions have not yet been established. Breeding of birds that have a higher ability to synthesize antimicrobial peptides in response to pathogens may be one such strategy. Because the ovary and oviduct are unique organs regulated by the endocrine system, consideration of the role of gonadotropic and gonadal hormones may also be important for the enhancement of local defense function. Physiological information about the mechanism of pathogen recognition and AvBD synthesis is essential to enhance immunodefense functions in the reproductive organs.