Atrophy of the corpus callosum in Alzheimer's disease versus healthy aging
Atrophy of the corpus callosum in Alzheimer's disease versus healthy aging
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DOI：
10.1111/j.1532-5415.1996.tb03736.x
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发表时间：
1996-07-01
影响因子：
6.3
通讯作者：
Carper, RA
中科院分区：
文献类型：
--
作者：
Janowsky, JS;Kaye, JA;Carper, RA
目的：研究阿尔茨海默病（AD）患者、健康老年受试者（HE）和前瞻性研究中出现认知功能减退或“初期痴呆”（ID）的受试者的胼胝体（CC）与小脑和笔相比萎缩性改变的特异性。设计：采用定量MRI进行年龄的横断面比较。60例HE受试者（平均年龄78.2岁;范围66-95岁）、20例ID受试者（平均年龄88.1岁;范围78-98岁）和33例AD受试者（平均年龄72.2岁;范围52-91岁）入组健康老龄化或AD的纵向研究。人口被选为最佳的健康，所有进行了检查，以排除医疗，神经和精神疾病。测量：定量MRI脑萎缩。结果：AD科目有较小的CC比HE或ID科目，谁没有不同。AD患者CC的所有三个扇区均小于HE或ID受试者。小脑和围栏的横截面积在组间没有差异。HE和LD受试者的CC大小随年龄增长而显著下降。未发现AD受试者的年龄相关性下降。区域萎缩的CC在AD受试者的认知功能显着相关，但不疾病的持续时间。结论：萎缩的CC区分HE和ID从AD受试者和跟踪这种疾病的认知能力下降。此外，最佳健康的受试者显示出与年龄相关的胼胝体大小下降。萎缩是特定的CC，皮质投射系统，并不发生在小脑或脑桥。
OBJECTIVE: To investigate the specificity of atrophic changes in the corpus callosum (CC) compared with the cerebellum and pens in patients with Alzheimer Disease (AD), healthy elderly subjects (HE), and a sample of prospectively studied subjects who have developed cognitive decline or ''incipient dementia'' (ID).DESIGN: Cross-sectional comparison by age using quantitative MRI.SETTING: Ambulatory research unit.PARTICIPANTS: Sixty HE subjects (mean age 78.2 years; range 66-95), 20 ID subjects (mean age 88.1 years; range 78-98) and 33 AD subjects (mean age 72.2 years;range 52-91) were enrolled in longitudinal studies of healthy aging or AD. The population was selected for optimal health; all were examined to exclude medical, neurological and psychiatric illnesses.MEASUREMENTS: Brain atrophy by quantitative MRI.RESULTS: AD subjects had smaller CC than HE or ID subjects, who did not differ from each other. All three sectors of the CC were smaller in AD than in HE or ID subjects. The cross sectional area of the cerebellum and pens did not differ between groups. HE and LD subjects showed a significant decline In CC size with age. No age-related decline was found for AD subjects. The regional atrophy of the CC in AD subjects was significantly related to cognitive function but not to disease duration.CONCLUSIONS: Atrophy of the CC differentiates HE and ID from AD subjects and tracks the cognitive decline of this disease. In addition, optimally healthy subjects show an age-related decline in callosum size. The atrophy is specific to the CC, a cortical projection system, and does not occur in cerebellum or pons.