Association between Serum Uric Acid Levels and Sleep Variables: Results from the National Health and Nutrition Survey 2005-2008.
Association between Serum Uric Acid Levels and Sleep Variables: Results from the National Health and Nutrition Survey 2005-2008.
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DOI：
10.1155/2012/363054
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发表时间：
2012
影响因子：
2
通讯作者：
Shankar A
中科院分区：
文献类型：
--
作者：
Wiener RC;Shankar A
睡眠呼吸障碍和高血清尿酸水平是心血管疾病的独立危险因素。然而，评估睡眠呼吸障碍和高尿酸血症之间关系的研究是有限的。我们检查了2005-2008年全国健康与营养调查中6491名年龄≥20岁的参与者的睡眠变量和高血清尿酸。睡眠变量包括睡眠时间、打鼾、打鼾和白天嗜睡。主要结局是血清尿酸水平高，定义为男性血清尿酸>为6.8 mg/dL，女性血清尿酸>为6.0 mg/dL。我们发现，在年龄、性别调整模型中，以及在人口统计学和生活方式/行为风险因素调整的多变量模型中，每周打鼾超过5晚、白天嗜睡和睡眠变量的加性综合评分与高血清尿酸相关。随着与临床结果相关的变量如抑郁症、糖尿病、高血压和高胆固醇水平的增加，这种关联减弱了。我们的研究结果表明，睡眠变量（包括打鼾、打鼾和白天嗜睡）与高血清尿酸水平之间存在正相关。
Sleep disordered breathing as well as high serum uric acid levels are independent risk factors for cardiovascular disease. However, studies evaluating the relationship between sleep-disordered breathing and hyperuricemia are limited. We examined the 2005–2008 National Health and Nutrition Examination survey's sleep variables and high serum uric acid among 6491 participants aged ≥20 years. The sleep variables included sleep duration, snoring, snorting, and daytime sleepiness. The main outcome was high serum uric acid level, defined as levels of serum uric acid >6.8 mg/dL in males and >6.0 mg/dL in females. We found that snoring more than 5 nights per week, daytime sleepiness, and an additive composite score of sleep variables were associated with high serum uric acid in the age- , sex-adjusted model and in a multivariable model adjusting for demographic and lifestyle/behavioral risk factors. The association was attenuated with the addition of variables related to clinical outcomes such as depression, diabetes, hypertension, and high-cholesterol levels. Our results indicate a positive relationship between sleep variables, including the presence of snoring, snorting, and daytime sleepiness, and high serum uric acid levels.