Near-Infrared Light Responsive Folate Targeted Gold Nanorods for Combined Photothermal-Chemotherapy of Osteosarcoma.
Near-Infrared Light Responsive Folate Targeted Gold Nanorods for Combined Photothermal-Chemotherapy of Osteosarcoma.
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DOI：
10.1021/acsami.7b03711
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发表时间：
2017-04
影响因子：
9.5
通讯作者：
Anna Li Volsi;C. Scialabba;V. Vetri;G. Cavallaro;M. Licciardi;G. Giammona
中科院分区：
文献类型：
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作者：
Anna Li Volsi;C. Scialabba;V. Vetri;G. Cavallaro;M. Licciardi;G. Giammona
提出了叶酸靶向的金纳米棒（GNR）作为骨肉瘤治疗的选择性疗法剂。羟基乙基）-d，用叶酸（phea-eDa-fa）功能化的L-甲胺，已合成作为GNR的涂层剂。大小，形状，Zeta电位，化学成分和水性稳定性。表达高水平的FRS并与人支气管上皮细胞（16HBE）和人类皮肤成纤维细胞（HDFA）进行比较（HDFA）。在NIR激光照射和作为出色的高温药物以及两种光子发光成像对比剂的作用时，也证明了拟议的叶酸靶向GNR。骨肉瘤模型。
Folate-targeted gold nanorods (GNRs) are proposed as selective theranostic agents for osteosarcoma treatment. An amphiphilic polysaccharide based graft-copolymer (INU-LA-PEG-FA) and an amino derivative of the α,β-poly(N-2-hydroxyethyl)-d,l-aspartamide functionalized with folic acid (PHEA-EDA-FA), have been synthesized to act as coating agents for GNRs. The obtained polymer-coated GNRs were characterized in terms of size, shape, zeta potential, chemical composition, and aqueous stability. They protected the anticancer drug nutlin-3 and were able to deliver it efficiently in different physiological media. The ability of the proposed systems to selectively kill tumor cells was tested on U2OS cancer cells expressing high levels of FRs and compared with human bronchial epithelial cells (16HBE) and human dermal fibroblasts (HDFa). The property of the nanosystems of efficiently controlling drug release upon NIR laser irradiation and of acting as an excellent hyperthermia agent as well as Two Photon Luminescence imaging contrast agents was demonstrated. The proposed folate-targeted GNRs have also been tested in terms of chemoterapeutic and thermoablation efficacy on tridimensional (3-D) osteosarcoma models.