Auditory cortex electrical stimulation suppresses tinnitus in rats.
Auditory cortex electrical stimulation suppresses tinnitus in rats.
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听觉皮层电刺激可抑制大鼠耳鸣。
DOI：
10.1007/s10162-010-0246-z
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Zhang,Xueguo
中科院分区：
文献类型：
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作者：
Zhang,Jinsheng;Zhang,Yupeng;Zhang,Xueguo
最近的临床研究表明，听觉皮层电刺激（ACES）在抑制耳鸣方面取得了可喜的成果。然而，ACES诱导的抑制作用在个体间的疗效差异很大，阻碍了其发展成为一种可靠的治疗方法。由于伦理原因，许多问题无法在患者中得到全面解决。为了寻找有效的刺激靶点和确定最佳的刺激策略，我们开发了第一个大鼠模型来测试通过ACES抑制音调诱导的耳鸣的行为证据。我们的行为结果表明，听觉皮层中所有通道（频带）的电刺激显著抑制耳鸣的行为证据，并增强了中枢水平的听力检测。耳鸣的这种抑制和听力检测的增强分别通过在10-12、14-16和26- 28 kHz下损害间隙检测的音调暴露的逆转和在10-12和26-28 kHz下损害前脉冲抑制来证明。相反，ACES不会引起动物的行为变化，这些动物在相同的音调暴露后没有表现出任何耳鸣和听力检测受损的行为证据。结果指出，耳鸣可能与受损的中央听觉处理比听力损失在周边水平。ACES诱导的耳鸣行为证据的抑制可能涉及异常中枢听觉处理的恢复。
Recent clinical studies have demonstrated that auditory cortex electrical stimulation (ACES) has yielded promising results in the suppression of patients’ tinnitus. However, the large variability in the efficacy of ACES-induced suppression across individuals has hindered its development into a reliable therapy. Due to ethical reasons, many issues cannot be comprehensively addressed in patients. In order to search for effective stimulation targets and identify optimal stimulation strategies, we have developed the first rat model to test for the suppression of behavioral evidence of tone-induced tinnitus through ACES. Our behavioral results demonstrated that electrical stimulation of all channels (frequency bands) in the auditory cortex significantly suppressed behavioral evidence of tinnitus and enhanced hearing detection at the central level. Such suppression of tinnitus and enhancement of hearing detection were respectively demonstrated by a reversal of tone exposure compromised gap detection at 10–12, 14–16, and 26–28 kHz and compromised prepulse inhibition at 10–12 and 26–28 kHz. On the contrary, ACES did not induce behavioral changes in animals that did not manifest any behavioral evidence of tinnitus and compromised hearing detection following the same tone exposure. The results point out that tinnitus may be more related to compromised central auditory processing than hearing loss at the peripheral level. The ACES-induced suppression of behavioral evidence of tinnitus may involve restoration of abnormal central auditory processing.