Brain activity at rest: a multiscale hierarchical functional organization
Brain activity at rest: a multiscale hierarchical functional organization
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DOI：
10.1152/jn.00895.2010
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发表时间：
2011-06-01
影响因子：
2.5
通讯作者：
Joliot, Marc
中科院分区：
文献类型：
--
作者：
Doucet, Gaelle;Naveau, Mikael;Joliot, Marc
Doucet G，Naveau M，Petit L，Delcroix N，Zago L，Crivello F，Jobard G，Tzourio-Mazoyer N，Mazoyer B，Mellet E，Joliot M.休息时的脑活动：多尺度层次功能组织。J Neurophysiol 105：2753 - 2763，2011.首次发表于2011年3月23日; doi：10.1152/jn.00895.2010. -在180名受试者的样本中，在有意识的休息状态下，用功能性MRI（fMRI）绘制了自发脑活动。使用独立成分分析（ICA）的每个单独的功能磁共振成像信号和ICA定义的组件跨学科的分类，一组23个静息状态网络（RN）被确定。使用0.01 - 0.1-Hz频带中的时间相关性分析评估每对RN之间的功能连接，并使用相应的相关系数集来获得23个RN的分层聚类。在最高的层次，我们发现两个相关的系统负责内在和外在的处理，分别。在较低的水平上，内在系统似乎被划分为三个模块，分别有助于自发思维的产生（M1a;默认模式），内部维护和信息操纵（M1b），以及认知控制和转换活动（M1c）。外部系统被发现由两个不同的模块组成：一个包括初级躯体感觉和听觉区域以及背侧注意网络（M2a），另一个包括视觉区域（M2b）。功能连接分析表明，M1b在内在系统的功能中发挥了核心作用，而M1c似乎介导了内在和外在系统之间的信息交换。
Doucet G, Naveau M, Petit L, Delcroix N, Zago L, Crivello F, Jobard G, Tzourio-Mazoyer N, Mazoyer B, Mellet E, Joliot M. Brain activity at rest: a multiscale hierarchical functional organization. J Neurophysiol 105: 2753-2763, 2011. First published March 23, 2011; doi: 10.1152/jn.00895.2010.-Spontaneous brain activity was mapped with functional MRI (fMRI) in a sample of 180 subjects while in a conscious resting-state condition. With the use of independent component analysis (ICA) of each individual fMRI signal and classification of the ICA-defined components across subjects, a set of 23 resting-state networks (RNs) was identified. Functional connectivity between each pair of RNs was assessed using temporal correlation analyses in the 0.01- to 0.1-Hz frequency band, and the corresponding set of correlation coefficients was used to obtain a hierarchical clustering of the 23 RNs. At the highest hierarchical level, we found two anticorrelated systems in charge of intrinsic and extrinsic processing, respectively. At a lower level, the intrinsic system appears to be partitioned in three modules that subserve generation of spontaneous thoughts (M1a; default mode), inner maintenance and manipulation of information (M1b), and cognitive control and switching activity (M1c), respectively. The extrinsic system was found to be made of two distinct modules: one including primary somatosensory and auditory areas and the dorsal attentional network (M2a) and the other encompassing the visual areas (M2b). Functional connectivity analyses revealed that M1b played a central role in the functioning of the intrinsic system, whereas M1c seems to mediate exchange of information between the intrinsic and extrinsic systems.