CSF acid-base regulation and ventilation during acute hypercapnia in the newborn dog.
CSF acid-base regulation and ventilation during acute hypercapnia in the newborn dog.
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新生犬急性高碳酸血症期间脑脊液酸碱调节和通气。
DOI：
10.1152/jappl.1981.50.3.566
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
W. Edwards
中科院分区：
文献类型：
--
作者：
E. Nattie;W. Edwards
我们研究了轻度麻醉新生幼犬的血液，脑脊液（CSF），脑离子组成和酸碱状态以及通气对急性呼吸性酸中毒（FICO 2 0.08）的反应。对照幼犬血浆离子和CSF-血浆离子分布比基本上与成人相似，而血液中存在轻度代偿性呼吸性酸中毒，CSF中PCO 2和[HCO 3-]略高于成人。幼犬脑组织含水量高于成年犬; Cl-空间较大;[Na+]、[Cl-]和[HCO 3-]含量较高，[K+]较低。在呼吸性酸中毒期间，CSF [HCO 3-]在15分钟时增加2.0 mmol/l，在3小时时增加6.2 mmol/l，定量反应与成人中观察到的反应相似。CSF [Na+] - [Cl-]的量随CSF [HCO 3-]的化学计量增加，表明这些离子在CSF [HCO 3-]反应中的机制参与。在脑组织中，水含量，[Cl-]和[Cl-]空间不变，但3小时[Na+]和[HCO 3-]增加。刺激通气，但幼犬的反应（以ml·min ~（-1）·Torr ~（-1）·body wt ~（-1）表示）小于成年犬。
We studied the response of blood, cerebrospinal fluid (CSF), and brain ionic composition and acid-base status as well as ventilation to acute respiratory acidosis (FICO2 0.08) in lightly anesthetized newborn puppies. Control puppy plasma ions and CSF-plasma ionic distribution ratios were essentially adultlike while in blood a mild, compensated respiratory acidosis was present, and in CSF, PCO2 and [HCO3-] were slightly higher than in adults. Brain tissue water content was higher in puppy vs. adult; the Cl- space was greater; the content of [Na+], [Cl-], and [HCO3-] were higher and [K+] lower. During respiratory acidosis, CSF [HCO3-] increased 2.0 mmol/l by 15 min and 6.2 mmol/l by 3 h, a response quantitatively like that observed in the adult. The quantity, CSF [Na+] -- [Cl-], increased stoichiometrically with CSF [HCO3-], indicating the mechanistic involvement of these ions in the CSF [HCO3-] response. In brain tissue, water content, [Cl-], and the [Cl-] space were unchanged, but by 3 h [Na+] and [HCO3-] were increased. Ventilation was stimulated but the response expressed as ml.min-1.Torr-1.body wt-1 was less in puppy than in adult.