Development of a library of 6-arylcoumarins as candidate fluorescent sensors.
Development of a library of 6-arylcoumarins as candidate fluorescent sensors.
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DOI：
10.1021/ol070142z
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发表时间：
2007-02
期刊：
影响因子：
5.2
通讯作者：
T. Hirano;Kenichi Hiromoto;H. Kagechika
中科院分区：
文献类型：
--
作者：
T. Hirano;Kenichi Hiromoto;H. Kagechika
[结构：见正文]。使溴代香豆素支架（1）与各种硼酸衍生物（2a_l）反应以提供6-芳基香豆素（3a_l）的文库。发现该库包含用于肽酶活性和一氧化氮的候选荧光传感器。
[structure: see text]. A bromocoumarin scaffold (1) was reacted with various boronic acid derivatives (2a-l) to afford a library of 6-arylcoumarins (3a-l). This library was found to contain candidate fluorescent sensors for peptidase activity and for nitric oxide.