Psychosocial versus physiological stress - Meta-analyses on deactivations and activations of the neural correlates of stress reactions.
Psychosocial versus physiological stress - Meta-analyses on deactivations and activations of the neural correlates of stress reactions.
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DOI：
10.1016/j.neuroimage.2015.06.059
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发表时间：
2015-10-01
期刊：
影响因子：
5.7
通讯作者：
Derntl B
中科院分区：
文献类型：
--
作者：
Kogler L;Müller VI;Chang A;Eickhoff SB;Fox PT;Gur RC;Derntl B
压力以各种形式和情况存在于日常生活中。两个经常调查的压力源是生理和心理压力。除了类似的主观和激素反应外，有人认为它们也有共同的神经基质。目前的研究使用激活可能性估计荟萃分析，以测试这一假设，通过整合以前的神经影像学研究的结果，对压力处理。报告的结果是集群级FWE校正。额下回（IFG）和前额叶（AI）是唯一的区域，表现出重叠激活的两个压力。生理应激分析表明，疼痛处理的认知和情感成分，如纹状体，纹状体，或中扣带皮层的一致激活。首先，对心理社会压力的分析显示，右侧上级颞回的激活和纹状体的失活是一致的。值得注意的是，纹状体的部分功能似乎是特定的：背侧纹状体在生理应激中被激活，而腹侧纹状体在心理应激中被灭活。额外的功能连接和解码分析进一步表征了这种功能异质性，并揭示了背侧纹状体与运动区和腹侧纹状体与奖励处理的更高关联。基于我们的元分析方法，IFG和AI的激活似乎表明了一种全局神经应激反应。虽然生理压力激活了运动性的战斗或逃跑反应，但在心理社会压力期间，注意力转向情绪调节和目标导向行为，奖励处理减少。我们的研究结果显示了区分生理和心理社会压力在神经参与中的意义。此外，在压力研究中，除了激活外，还强烈建议评估失活。
Stress is present in everyday life in various forms and situations. Two stressors frequently investigated are physiological and psychosocial stress. Besides similar subjective and hormonal responses, it has been suggested that they also share common neural substrates. The current study used activation-likelihood-estimation meta-analysis to test this assumption by integrating results of previous neuroimaging studies on stress processing. Reported results are cluster-level FWE corrected. The inferior frontal gyrus (IFG) and the anterior insula (AI) were the only regions that demonstrated overlapping activation for both stressors. Analysis of physiological stress showed consistent activation of cognitive and affective components of pain processing such as the insula, striatum, or the middle cingulate cortex. Contrarily, analysis across psychosocial stress revealed consistent activation of the right superior temporal gyrus and deactivation of the striatum. Notably, parts of the striatum appeared to be functionally specified: the dorsal striatum was activated in physiological stress, whereas the ventral striatum was deactivated in psychosocial stress. Additional functional connectivity and decoding analyses further characterized this functional heterogeneity and revealed higher associations of the dorsal striatum with motor regions and of the ventral striatum with reward processing. Based on our meta-analytic approach, activation of the IFG and the AI seems to indicate a global neural stress reaction. While physiological stress activates a motoric fight-or-flight reaction, during psychosocial stress attention is shifted towards emotion regulation and goal-directed behavior, and reward processing is reduced. Our results show the significance of differentiating physiological and psychosocial stress in neural engagement. Furthermore, the assessment of deactivations in addition to activations in stress research is highly recommended.