Pituitary response to LHRH in hypothyroid women.
Pituitary response to LHRH in hypothyroid women.
复制标题
甲状腺功能减退女性的垂体对 LHRH 的反应。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
Tredway Dr
中科院分区：
文献类型：
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作者：
Drake Ts;O'Brien Wf;Tredway Dr
本研究旨在描述绝经前妇女甲状腺功能减退和甲状腺功能正常时期的垂体功能。研究了6名基础促甲状腺激素（TSH）水平高于10 microU/ml的受试者。在输注前30、15和0分钟，通过放射免疫测定法测定雌二醇（E2）、催乳素（PRL）、卵泡刺激素（FSH）和黄体生成素（LH）水平。通过每2小时快速输注10 μ g促黄体生成素释放激素（LHRH）共6小时来评估垂体功能。然后在6小时研究期间每30分钟采集一次FSH和LH样本。在所有6例受试者中，无论基础E2水平如何，在甲状腺功能减退期间均观察到基础促性腺激素显著升高（P 0.05）。在所有6例患者中，垂体敏感性和储备与基础E2水平显著相关（P <0.05），但不受甲状腺功能减退的影响。它的结论是，垂体对LHRH的反应是不改变甲状腺功能减退的妇女，但慢性基础促性腺激素的升高可能部分解释了无排卵，所以往往伴随着这种疾病。
This study was designed to characterize pituitary function in premenopausal women during hypothyroid and euthyroid periods. Six subjects with basal thyroid-stimulating hormone (TSH) levels above 10 microU/ml were studied. Estradiol (E2), prolactin (PRL), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels were measured by radioimmunoassay at 30, 15, and 0 minutes before infusion. Pituitary function was evaluated by rapid infusion of 10 micrograms of luteinizing hormone-releasing hormone (LHRH) every 2 hours for a total of 6 hours. Samples were then obtained for FSH and LH every 30 minutes for the duration of the 6-hour study. A significant elevation in basal gonadotropins was observed during the hypothyroid period regardless of basal E2 levels in all 6 subjects (P .05). In all 6 patients pituitary sensitivity and reserve correlated significantly with basal E2 levels (P < .05), but were not altered by the hypothyroid condition. It is concluded that pituitary responsiveness to LHRH is not altered in hypothyroid women, but that chronic elevation of basal gonadotropins may in part explain the anovulation that so often accompanies this disorder.