Gender differences in the left inferior frontal gyrus in normal children
Gender differences in the left inferior frontal gyrus in normal children
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DOI：
10.1016/j.neuroimage.2004.01.010
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发表时间：
2004-06-01
期刊：
影响因子：
5.7
通讯作者：
Toga, AW
中科院分区：
文献类型：
--
作者：
Blanton, RE;Levitt, JG;Toga, AW
这项研究检测了46名正常儿童和青少年(25名女性，平均年龄：11.08，SD：3.07；21名男性，平均年龄：10.76，SD：2.61)的额叶亚区，以评估年龄和性别对体积测量和半球不对称的影响。在高分辨率磁共振成像(MRI)数据中手动勾画上、中、下和眼眶-额部灰质、白色和脑脊液(CSF)体积，以评估可能的形态变化。我们报告了男孩左侧额下回白质随年龄的显著增加(P=0.007)。此外，男孩的左侧IFG明显大于女孩(P=0.004)。与女孩相比，男孩的灰质体积增加了，即使在校正了总大脑体积后也是如此。此外，研究还发现，男孩有显著的右脑和左脑不对称模式，在总大脑体积、总脑白质、MFG白质和SFG白质方面右半球体积更大(P<；0.001)。女孩在总脑和三叉神经节白质中表现出显著的右和左不对称模式(P<；0.001)。这些发现表明，在男孩的正常发育过程中，IFG继续发生改变，并且男孩和女孩在IFG灰质上存在显著的性别差异，这可能与语言发育和语言偏侧化的性别差异有关。(C)2004 Elsevier Inc.保留所有权利。
This study examined frontal lobe subregions in 46 normal children and adolescents (25 females, mean age: 11.08, SD: 3.07; and 21 males, mean age: 10.76, SD: 2.61) to assess the effects of age and gender on volumetric measures as well as hemispheric asymmetries. Superior, middle, inferior, and orbito-frontal gray, white, and cerebrospinal (CSF) volumes were manually delineated in high-resolution magnetic resonance imaging (MRI) data to assess possible morphological changes. We report a significant age-related increase in the white matter of the left inferior frontal gyrus (IFG) in boys (P = 0.007). Additionally, the left IFG was significantly larger in boys compared to girls (P = 0.004). Boys showed increased gray matter volume relative to girls even after correcting for total cerebral volume. Also, boys were found to have significant Right > Left asymmetry patterns with greater right hemispheric volumes for total cerebral volume, total cerebral white matter, MFG white matter, and SFG white matter (P < 0.001). Girls showed significant Right > Left asymmetry patterns in total cerebral and SFG white matter (P < 0.001). These findings suggest continued modification of the IFG during normal development in boys, and significant gender differences in IFG gray matter between boys and girls that may be possibly linked to gender differences in speech development and lateralization of language. (C) 2004 Elsevier Inc. All rights reserved.