Many mechanisms mediating mobilization: an alliterative review.
Many mechanisms mediating mobilization: an alliterative review.
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DOI：
10.1097/moh.0b013e3283477962
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发表时间：
2011-07
影响因子：
3.2
通讯作者：
Pelus LM
中科院分区：
文献类型：
--
作者：
Hoggatt J;Pelus LM
血细胞的产生由造血干细胞 (HSC) 维持，这些细胞位于骨髓内的特殊位置。粒细胞集落刺激因子 (G-CSF) 治疗会导致 HSC 从骨髓微环境中流出并运输至外周血，这一过程称为“动员”。尽管动员现象早已为人所知，并在临床上用于获取用于移植的 HSC，但介导 HSC 释放的机制尚不完全清楚。我们讨论了在定义 G-CSF 诱导动员机制方面的最新进展和争议。新的报告定义了常驻单核细胞/巨噬细胞在维持微环境细胞中的作用，这种作用在 G-CSF 治疗后会减弱，这表明了一种新的动员机制。虽然成骨细胞据报道是 HSC 生态位的主要组成部分，但新的结果表明，一个独特的生态位由受神经支配的间充质干细胞组成。调节生物活性脂质信号传导也有助于动员，并可能定义未来的治疗策略。 G-CSF 的造血动员主要是通过直接和间接机制改变骨髓生态位介导的，而不是直接改变 HSC 功能。进一步了解介导动员的过程将增进我们对 HSC 生态位的细胞和分子成分的理解。
Blood cell production is maintained by hematopoietic stem cells (HSC) that reside in specialized niches within bone marrow. Treatment with granulocyte-colony stimulating factor (G-CSF) causes HSC egress from bone marrow niches and trafficking to the peripheral blood, a process termed “mobilization”. Although the mobilization phenomenon has been known for some time and is utilized clinically to acquire HSC for transplant, the mechanisms mediating HSC release are not completely understood. We discuss recent advances and controversies in defining mechanisms responsible for G-CSF induced mobilization. New reports define a role for resident monocytes/macrophages in maintaining niche cells, which is diminished after G-CSF treatment, suggesting a new mechanism for mobilization. While osteoblasts have been reported to be a primary component of the HSC niche, new results suggest a unique niche composed of innervated mesenchymal stem cells. Modulating bioactive lipid signaling also facilitates mobilization, and may define a future therapeutic strategy. Hematopoietic mobilization by G-CSF is primarily mediated by alterations to the bone marrow niche by both direct and indirect mechanisms, rather than directly altering HSC function. Further understanding of the processes mediating mobilization will advance our understanding on the cellular and molecular components of the HSC niche.