Synthesis of the Branched Tetrasaccharide Fragment of Saccharomicin A
Synthesis of the Branched Tetrasaccharide Fragment of Saccharomicin A
复制标题
DOI：
10.1021/acs.orglett.2c04081
复制
发表时间：
2023-01-10
期刊：
影响因子：
5.2
通讯作者：
Bennett，Clay S.
中科院分区：
文献类型：
--
作者：
Garreffi，Brian P.;Maney，Akash P.;Bennett，Clay S.
报道了一种利用1-OTB供体立体选择性地合成α和β连接的双糖的方法，合成了糖霉素A的支链四糖片段。用BSP/Tf2O将二糖结合，以72%的产率得到四糖片段作为单一的α-异构体。这种分枝的四糖片段可作为糖霉素A的供体和受体合成更大的片段。
A synthesis of the branched tetrasaccharide fragment of saccharomicin A using 1-OTBS donors to stereoselectively synthesize both α- and β-linked disaccharides is reported. The disaccharides were united using BSP/Tf2O to afford the tetrasaccharide fragment as a single α-anomer in 72% yield. This branched tetrasaccharide fragment can be used as donor and acceptor species to synthesize larger fragments of saccharomicin A.