Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients
Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients
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T1-2N0 舌癌患者局部复发的预测因子
DOI：
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发表时间：
2013
影响因子：
2.8
通讯作者：
M. Umeda
中科院分区：
文献类型：
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作者：
S. Yanamoto;S. Yamada;Hidenori Takahashi;G. Kawasaki;H. Ikeda;T. Shiraishi;S. Fujita;Tohru Ikeda;I. Asahina;M. Umeda
口腔舌鳞状细胞癌（OTSCC）的局部复发一直被认为是一个预后不良的实体的生存率。本研究的目的是评估早期OTSCC局部复发的发生率，并确定局部复发的重要危险因素。我们回顾性分析了58例T1- 2N 0 OTSCC根治性手术患者的记录。本研究中局部复发率和区域复发率分别为10.3%（6/58例患者）和15.5%（9/58例患者）。局部复发患者的生存率为66.7%，显著低于无局部复发患者的生存率（96.2%），而局部复发与无局部复发患者的生存率无显著性差异。浸润方式（POI）、新辅助化疗（NAC）和手术切缘状态被确定为影响局部复发的因素。特别是，深手术切缘的状态是一个高潜在的独立风险因素。在许多NAC治疗的病例中，深手术切缘被紧密切除，这表明NAC可能导致局部复发和不良结局。未观察到NAC的疗效，表明早期OTSCC的标准治疗是单独手术。
Locoregional recurrence of oral tongue squamous cell carcinoma (OTSCC) has been considered a poor prognostic entity in terms of survival rate. The purpose of this study was to evaluate the incidence of locoregional recurrence and to identify significant risk factors for locoregional recurrence in early-stage OTSCC. We retrospectively reviewed the records of 58 patients who underwent radical surgery for T1-2N0 OTSCC. The local recurrence and regional recurrence rates were 10.3 % (6/58 patients) and 15.5 % (9/58 patients) in this study, respectively. The survival rate of patients with local recurrence was 66.7 %, which was significantly lower than that (96.2 %) of patients without local recurrence, whereas the survival rates of patients with or without regional recurrence were not significantly difference. Pattern of invasion (POI), neoadjuvant chemotherapy (NAC) and the status of the surgical margin were identified as factors influencing local recurrence. In particular, the status of the deep surgical margin was a high potential independent risk factor. The deep surgical margin was resected closely in many NAC-treated cases, suggesting that NAC may lead to local recurrence and a poor outcome. No efficacy of NAC was observed, suggesting that the standard treatment for early OTSCC is surgery alone.
口腔癌治疗的当前概念——手术。
影响因子：
4.8
作者：
Shah, Jatin P.;Gil, Ziv
通讯作者：
Gil, Ziv
影响因子：
158.5
作者：
Bernier, J;Domenge, C;van Glabbeke, M
通讯作者：
van Glabbeke, M