Motion or activity: Their role in intra- and inter-subject variation in fMRI
Motion or activity: Their role in intra- and inter-subject variation in fMRI
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DOI：
10.1016/j.neuroimage.2005.02.021
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发表时间：
2005-07-01
期刊：
影响因子：
5.7
通讯作者：
Paulson, OB
中科院分区：
文献类型：
--
作者：
Lund, TE;Norgaard, MD;Paulson, OB
功能磁共振成像(FMRI)具有非侵入性测量大脑活动的潜力。通常，所谓的激活图像实际上是有阈值的统计参数图。这些地图具有很大的会议间可变性。当将功能磁共振应用于术前计划时，这尤其有问题，因为对受试者内的精确度有更高的要求。这项研究的目的是调查在观察到的fMRI激活中，残余运动伪影对受试者内和受试者间变异性的影响。研究人员对10名受试者进行了三种不同的词汇生成任务。其中两名受试者在10天不同的时间里使用相同的范式进行了10次检查。我们系统地研究了一种校正残差运动效应的方法：在通用线性模型(GLM)的设计矩阵中包含描述运动相关效应的回归变量。使用和不使用残差运动伪影模型对数据进行分析，并使用F对比分析对会议间方差的影响。在分析中加入运动参数显著降低了受试者内部和受试者间的方差。(C)2005 Elsevier Inc.保留所有权利。
Functional MRI (fMRI) carries the potential for non-invasive measurements of brain activity. Typically, what are referred to as activation images are actually thresholded statistical parametric maps. These maps possess large inter-session variability. This is especially problematic when applying fMRI to pre-surgical planning because of a higher requirement for intra-subject precision. The purpose of this study was to investigate the impact of residual movement artefacts on intrasubject and inter-subject variability in the observed fMRI activation. Ten subjects were examined using three different word-generation tasks. Two of the subjects were examined 10 times on 10 different days using the same paradigms. We systematically investigated one approach of correcting for residual movement effects: the inclusion of regressors describing movement-related effects in the design matrix of a General Linear Model (GLM). The data were analysed with and without modeling the residual movement artefacts and the impact on inter-session variance was assessed using F-contrasts. Inclusion of motion parameters in the analysis significantly reduced both the intrasubject as well as the inter-subject-variance. (c) 2005 Elsevier Inc. All rights reserved.