Incidence, Risk Factors, and Outcomes of Rhabdomyolysis in Hospitalized Patients With COVID-19 Infection.
Incidence, Risk Factors, and Outcomes of Rhabdomyolysis in Hospitalized Patients With COVID-19 Infection.
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DOI：
10.7759/cureus.19802
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发表时间：
2021-11
期刊：
影响因子：
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通讯作者：
Mehta S
中科院分区：
文献类型：
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作者：
Albaba I;Chopra A;Al-Tarbsheh AH;Feustel PJ;Mustafa M;Oweis J;Parimi SA;Santelises Robledo FM;Mehta S
前言：关于新冠肺炎感染住院患者中横纹肌溶解的患病率和临床特征的研究很少。这项研究的目的是调查住院的新冠肺炎感染患者发生横纹肌溶解的发生率、临床特征和预后。方法：本研究是对2020年3月8日至2021年1月11日收治的所有新冠肺炎患者的单中心回顾分析。所有入院时肌酸激酶(CK)水平正常的患者均包括在内。横纹肌溶解定义为CK水平高于正常上限(即1125U/L)的5倍以上。我们比较了发生横纹肌溶解的患者和没有发生横纹肌溶解的患者的临床特征和结果。结果：新冠肺炎感染住院患者横纹肌溶解发生率为9.2%。两组患者在合并症和临床特征方面无显著差异。此外，在发生严重新冠肺炎感染(72.7%vs 54.6%，p=0.1)、死亡率(27.3%vs 23.9%，p=0.72)、急性肾损伤(59.1%vs 42.7%，p=0.14)或需要重症监护病房(72.7%vs 51.4%，p=0.051)方面，差异无统计学意义。然而，横纹肌溶解组患者出院后需要身体康复的比例较高(40.9%对19.3%，p=0.02)。结论：新冠肺炎感染住院患者横纹肌溶解的总发生率较高(9.2%)。横纹肌溶解的出现与疾病严重程度的增加无关。与不患有横纹肌溶解的患者相比，患有横纹肌溶解的患者更需要身体康复。
Introduction: There is a paucity of studies examining the prevalence and clinical characteristics of rhabdomyolysis in hospitalized patients with COVID-19 infection. The purpose of this study is to examine the incidence, clinical characteristics, and outcome of hospitalized patients with COVID-19 infection who develop rhabdomyolysis. Methodology: This is a single-center retrospective analysis of all hospitalized patients with COVID-19 admitted between March 8, 2020, and January 11, 2021. All patients with creatinine kinase (CK) levels available during the hospital admission were included. Rhabdomyolysis was defined as an elevation in CK level higher than five times the upper limit of normal (i.e., 1125 U/L). We compared clinical characteristics and outcomes of patients who developed rhabdomyolysis with patients who did not develop rhabdomyolysis. Results: The incidence of rhabdomyolysis in hospitalized patients with COVID-19 infection was 9.2%. There was no significant difference noted in comorbidities and clinical characteristics between the two groups. Moreover, there was no significant difference noted in the presence of severe COVID-19 infection (72.7% vs 54.6%, p = 0.1), mortality (27.3% vs 23.9%, p = 0.72), acute kidney injury (59.1% vs 42.7%, p = 0.14), or need for intensive care unit (ICU) care (72.7% vs 51.4%, p = 0.051). However, a higher percentage of patients in the rhabdomyolysis group required physical rehabilitation after discharge (40.9% vs 19.3%, p = 0.02). Conclusion: The overall incidence of rhabdomyolysis in hospitalized patients with COVID-19 infection was high (9.2%). The presence of rhabdomyolysis was not associated with the increased severity of the disease. Patients with rhabdomyolysis more frequently required physical rehabilitation compared to those without rhabdomyolysis.