Two new indole-diterpenoids from the marine-derived fungus Penicillium sp. KFD28
Two new indole-diterpenoids from the marine-derived fungus Penicillium sp. KFD28
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DOI：
10.1080/10286020.2020.1849150
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发表时间：
2020-11-13
影响因子：
1.7
通讯作者：
Zhao, You-Xing
中科院分区：
文献类型：
--
作者：
Chen, Ming-Yang;Xie, Qing-Yi;Zhao, You-Xing
从海洋真菌青霉菌（Penicillium sp. KFD28）中分离到两个新化合物epipaxilline(1)和penerpene J(2)。通过光谱学方法和ECD分析确定了它们的结构和绝对构型。化合物1和2对PTP1B具有抑制活性，IC50值分别为31.5和9.5 μ M，化合物2对TCPTP也具有抑制活性，IC50值为14.7 μ M。
Two new compounds named epipaxilline (1) and penerpene J (2) were isolated from the marine-derived fungus Penicillium sp. KFD28. Their structures including absolute configurations were determined on the basis of spectroscopic methods and ECD analysis. Compounds 1 and 2 showed inhibitory activities against PTP1B with IC50 values of 31.5 and 9.5 mu M, respectively, and compound 2 also showed inhibitory activities against TCPTP with IC50 value of 14.7 mu M.