Vaginal dysbiosis dominated by miscellaneous bacteria correlates with more severe clinical symptoms.
Vaginal dysbiosis dominated by miscellaneous bacteria correlates with more severe clinical symptoms.
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DOI：
10.1016/j.meegid.2019.104138
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发表时间：
2019-12
期刊：
影响因子：
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通讯作者：
Zuyi Zhou;Wenli Tang;Jinxia Ou;Pan Li;Yongji Ling;Yanli Lv;Hongwei Zhou;Muxuan Chen
中科院分区：
文献类型：
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作者：
Zuyi Zhou;Wenli Tang;Jinxia Ou;Pan Li;Yongji Ling;Yanli Lv;Hongwei Zhou;Muxuan Chen
随着下一代测序方法的发展，阴道微生物组的生态失调模式已在世界范围内得到描述，但生态失调与临床症状之间的相关性对于理解阴道微生物组-宿主相互作用至关重要，在很大程度上尚不清楚。本研究确定了4种类型的社区状态在88名妇女阴道微生态失调。这些群落状态类型（CSTs）以非惰性乳酸杆菌（CST 1）、惰性乳酸杆菌（CST 2）和葡萄加德纳菌（CST 3）以及除上述三种之外的多种优势种（CST 4）为主。我们发现，与CST 3相比，CST 4的女性中尿痛或腰痛更普遍，CST 4的女性中宫颈肥大比CST 2和CST 3的女性更普遍。这些结果表明，CST 4患者可能有更大的阴道症状倾向，具体微生物与宿主症状相关性的详细机制应进一步研究。
With the development of next-generation sequencing methods, dysbiosis patterns of the vaginal microbiome have been described worldwide, but the correlation between dysbiosis and clinical symptoms, which is crucial for understanding the vaginal microbiome-host interaction, is largely unknown. The present study identified 4 types of community states in 88 women with vaginal dysbiosis. These community state types (CSTs) were dominated by non-inersLactobacillus(CST1),L.iners(CST2),and Gardnerella vaginalis (CST3),and a variety of dominant species other than the above three (CST4). We found that urodynia or lumbodynia was more prevalent in women with CST4 than in women with CST3, and cervical hypertrophy was more prevalent in women with CST4 than in women with CST2 and CST3. These results indicate that patients in CST4 may have a greater tendency of vaginal symptoms, and the detailed mechanisms underlying these correlations of specific microbes with host symptoms should be further studied.