Persistent oxidative stress in colorectal carcinoma patients
Persistent oxidative stress in colorectal carcinoma patients
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DOI：
10.1002/ijc.10610
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发表时间：
2002-10-01
影响因子：
6.4
通讯作者：
Olinski, R
中科院分区：
文献类型：
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作者：
Gackowski, D;Banaszkiewicz, Z;Olinski, R
我们研究了与对照组相比，结肠癌中淋巴细胞DNA中8-氧代-2 '-脱氧鸟苷（8-oxodGuo）的水平是否更高。还确定了可能影响氧化应激的因素，如抗氧化剂维生素和尿酸。血液样品从55名健康人和43名结肠癌的对照组获得。8-用高效液相色谱法测定过氧化氢水平和维生素浓度。结肠癌患者血清8-oxodGuo水平显著高于对照组，而维生素和尿酸水平显著低于对照组。因此，抗氧化维生素浓度的降低以及尿酸含量的降低可能是结直肠癌患者血液中促氧化环境形成的原因。(C)2002 Wiley-Liss，Inc.
We examine whether the level of 8-oxo-2'-deoxyguanosine (8-oxodGuo) in lymphocytes DNA is higher in colon cancer when compared to the control group. Factors that may influence oxidative stress such as antioxidant vitamins and uric acid were also determined. Blood samples were obtained from a control group of 55 healthy persons and 43 colon cancers. 8-OxodGuo level and the vitamins concentration were measured by high-performance liquid chromatography. The levels of 8-oxodGuo were significantly higher whereas the concentrations of the vitamins and uric acid were significantly lower in colon cancer patients than in control group. Therefore, the decreased concentration of antioxidant vitamins together with lower amount of uric acid may be responsible for the formation of pro-oxidative environment in blood of colorectal carcinoma patients. (C) 2002 Wiley-Liss, Inc.