Nitric Oxide Adsorption and Delivery in Flexible MIL-88(Fe) Metal-Organic Frameworks
Nitric Oxide Adsorption and Delivery in Flexible MIL-88(Fe) Metal-Organic Frameworks
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DOI：
10.1021/cm304037x
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发表时间：
2013-05-14
影响因子：
8.6
通讯作者：
Morris, R. E.
中科院分区：
文献类型：
--
作者：
McKinlay, A. C.;Eubank, J. F.;Morris, R. E.
生物活性一氧化氮（NO）的吸附和释放在一系列具有MIL-88结构类型的高度柔性的二羧酸铁（III）MOF上进行评价，所述MIL-88结构类型具有由极性基团（NO2）官能化或未官能化的富马酸或对苯二甲酸间隔基。2OH）。如非原位X射线粉末衍射和原位IR光谱所证明的，似乎如果收缩的干燥形式的MIL-88在NO存在下不扩展其结构，非常窄的孔和铁多面体的三聚体的组合导致显著量的NO的吸附（非常窄的孔）和/或化学吸附[铁（II）或铁（III）配位不饱和金属位点（CUS）]。在水蒸气下或在模拟体液中的NO的递送不超过总吸附量的20%范围，这可能是由于在吸附/解吸设置和化学发光释放测试之间发生的部分释放。然而，其中一些固体在很长一段时间（>16小时）内在生物水平上表现出显着的释放，这使得这些生物相容性和可生物降解的MOF对于NO的受控释放很有意义。
Adsorption and release of the biologically active nitric oxide (NO) was evaluated over a series of highly flexible iron(III) dicarboxylate MOFs of the MIL-88 structure type, bearing fumaric or terephthalic spacer functionalized or not by polar groups (NO2. 2OH). As evidenced by ex situ X-ray powder diffraction and in situ IR spectroscopy, it appears that if the contracted dried forms of MIL-88 do not expand their structures in the presence of NO, the combination of very narrow pores and trimers of iron polyhedra leads to the adsorption of significant amounts of NO either physisorbed (very narrow pores) and/or chemisorbed [iron(II) or iron(III) coordinatively unsaturated metal sites (CUS)]. The delivery of NO under vapor of water or in simulated body fluid does not exceed 20% range of the total adsorbed amount probably due to a partial release that occurs between the adsorption/desorption setup and the chemiluminescence release tests. Some of these solids nevertheless exhibit a significant release at the biological levels over a long period of time (>16 h) that make these biocompatible and biodegradable MOFs of interest for the controlled release of NO.