Forty Years Trends in Timing of Pubertal Growth Spurt in 157,000 Danish School Children
Forty Years Trends in Timing of Pubertal Growth Spurt in 157,000 Danish School Children
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DOI：
10.1371/journal.pone.0002728
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发表时间：
2008-07-16
期刊：
影响因子：
3.7
通讯作者：
Juul, Anders
中科院分区：
文献类型：
--
作者：
Aksglaede, Lise;Olsen, Lina W.;Juul, Anders
背景：进入青春期是生殖生活的一个重要里程碑，青春期时间的长期变化可能是人群总体生殖健康的重要指标。青春期过早与一些心理社会和健康问题有关。我们研究的目的是确定一大批学童的青春期生长突增 (OGS) 开始年龄和青春期身高峰值速度 (PHV) 是否显示出四十年来的长期趋势。方法和结果：对 1930 年至 1969 年出生的所有在哥本哈根市上小学的儿童进行了年度身高测量。 135,223 名女孩和 21,612 名男孩符合确定 OGS 年龄和 PHV 年龄的标准。这些生理事件在我们的计算机方法中被用作青春期发育的标志，以评估研究期间（出生年份 1930 至 1969 年）青春期成熟的任何长期趋势。在此期间，女孩和男孩的 OGS 年龄分别显着下降 0.2 和 0.4 岁，而女孩和男孩的 PHV 年龄分别显着下降 0.5 和 0.3 岁。 1940 年至 1955 年间出生的儿童的下降呈非线性趋势，并趋于平稳。男孩的青春期持续时间（根据 OGS 年龄与 PHV 年龄之间的差异定义）略有增加，而女孩则有所下降。结论：我们发现 OGS 和 PHV 年龄下降表明 1930 年至 1969 年间出生的丹麦儿童存在性成熟提前的长期趋势。青春期持续时间仅观察到微小变化。通过 OGS 和 PHV 时的年龄差异进行评估。
Background: Entering puberty is an important milestone in reproductive life and secular changes in the timing of puberty may be an important indicator of the general reproductive health in a population. Too early puberty is associated with several psychosocial and health problems. The aim of our study was to determine if the age at onset of pubertal growth spurt (OGS) and at peak height velocity (PHV) during puberty show secular trends during four decades in a large cohort of school children.Methods and Findings: Annual measurements of height were available in all children born from 1930 to 1969 who attended primary school in the Copenhagen Municipality. 135,223 girls and 21,612 boys fulfilled the criteria for determining age at OGS and age at PHV. These physiological events were used as markers of pubertal development in our computerized method in order to evaluate any secular trends in pubertal maturation during the study period (year of birth 1930 to 1969). In this period, age at OGS declined statistically significantly by 0.2 and 0.4 years in girls and boys, respectively, whereas age at PHV declined statistically significantly by 0.5 and 0.3 years in girls and boys, respectively. The decline was non-linear with a levelling off in the children born between 1940 and 1955. The duration of puberty, as defined by the difference between age at OGS and age at PHV, increased slightly in boys, whereas it decreased in girls.Conclusion: Our finding of declining age at OGS and at PHV indicates a secular trend towards earlier sexual maturation of Danish children born between 1930 and 1969. Only minor changes were observed in duration of puberty assessed by the difference in ages at OGS and PHV.