Differential expression of the immediate early genes FOS and ZENK following auditory stimulation in the juvenile male and female zebra finch
Differential expression of the immediate early genes FOS and ZENK following auditory stimulation in the juvenile male and female zebra finch
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DOI：
10.1016/s0169-328x(03)00288-2
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发表时间：
2003-08-19
期刊：
影响因子：
--
通讯作者：
Wade, J
中科院分区：
文献类型：
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作者：
Bailey, DJ;Wade, J
成年斑胸草雀（Taeniopygia guttata）的大脑对同种物种的歌声进行了调整。在成年雄性中，尾内侧新纹状体（NCM）对斑胸草雀歌声的反应，而在成年雌性中，NCM和海马（HP）在暴露于斑胸草雀歌声后比其他听觉刺激更活跃。尾侧腹侧纹状体（cHV）在两种性别也响应歌曲，但在女性没有选择性的NCM和HP。虽然我们对成年人的知觉回路了解很多，但对其发展的了解却很少。本研究暴露d30男性和女性斑胸草雀同种或异种的歌曲，音调或沉默，并检查密度的FOS和ZENK免疫反应核的NCM，cHV和HP。两个即刻早期基因的性别和听觉刺激条件之间存在显著的交互作用，但方向相反。也就是说，在这三个地区，福斯inummorreactive神经元增加，在女性介绍同种歌曲，男性没有表现出刺激曝光的影响。与此相反，ZENK阳性神经元的密度增加，男性，但不是女性，以下斑胸草雀歌曲曝光。FOS的结果表明，歌曲感知所需的一些神经反应可能在女性中比男性更早发展; ZENK诱导的数据表明相反。总体而言，少年立即早期基因激活的差异表明，男性和女性采用不同的神经机制的歌曲感知或发展轨迹导致共同的神经反应不同。(C)2003 Elsevier B. V.保留所有权利。
The brains of adult zebra finches (Taeniopygia guttata) are tuned to the songs of conspecifics. In adult males, the caudomedial neostriatum (NCM) responds to zebra finch song, and in adult females the NCM and hippocampus (HP) are active following exposure to zebra finch song more than other auditory stimuli. The caudal hyperstriatum ventrale (cHV) in both sexes also responds to song, but in females not as selectively as the NCM and HP. While much is known about the adult perceptual circuit, less is known about its development. The present study exposed d30 male and female zebra finches to conspecific or heterospecific song, tones or silence, and examined the densities of FOS- and ZENK-immunoreactive nuclei in the NCM, cHV and HP. Significant interactions existed between sex and auditory stimulus condition for both immediate early genes, but they were in opposite directions. That is, across the three regions, FOS-inummoreactive neurons were increased in females following presentation of conspecific songs; males did not show an effect of stimulus exposure. In contrast, the density of ZENK-positive neurons was increased in males, but not females, following zebra finch song exposure. The FOS results demonstrate that some neural responses required for song perception may develop earlier in females than males; data on ZENK induction suggest the opposite. Overall, differences in juvenile immediate early gene activation suggest either that males and females employ divergent neural mechanisms for song perception or that the developmental trajectories leading to common neural responses differ. (C) 2003 Elsevier B.V. All rights reserved.