Polyene antibiotics from Streptomyces mediocidicus
Polyene antibiotics from Streptomyces mediocidicus
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DOI：
10.1021/np060542f
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发表时间：
2007-02-01
影响因子：
5.1
通讯作者：
Keiko, Tabei
中科院分区：
文献类型：
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作者：
Cai, Ping;Kong, Fangming;Keiko, Tabei
从中杀链霉菌ATCC 23936中分离得到三种多烯抗生素，即中霉素A（1）、B（2）和氯红霉素（3）。它们的结构通过广泛的NMR研究结合化学反应和MS/MS裂解分析进行了鉴定。所有三种化合物都是由共轭氧代三烯基团和六烯部分组成的线性多烯。化合物1和2是新的多烯化合物。所有三个化合物在体外表现出广谱的抗真菌活性。
Three polyene antibiotics, mediomycins A (1), B (2), and clethramycin (3), were isolated from Streptomyces mediocidicus ATCC23936. Their structures were elucidated through extensive NMR study coupled with chemical reactions and MS/MS fragmentation analysis. All three compounds are linear polyenes consisting of a conjugated oxo-triene group and a hexaene moiety. Compounds 1 and 2 are new polyenes. All three compounds demonstrated a broad spectrum of antifungal activity in vitro.