Artery buckling affects the mechanical stress in atherosclerotic plaques.
Artery buckling affects the mechanical stress in atherosclerotic plaques.
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DOI：
10.1186/1475-925x-14-s1-s4
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发表时间：
2015
影响因子：
3.9
通讯作者：
Han HC
中科院分区：
文献类型：
--
作者：
Sanyal A;Han HC
动脉迂曲常见于高血压和动脉粥样硬化患者。虽然在管腔压力下动脉粥样硬化斑块中的机械应力已被广泛研究，但动脉粥样硬化动脉的机械稳定性以及随后对斑块应力的影响仍然未知。为此，我们研究了具有对称和不对称斑块的模型狭窄冠状动脉的屈曲和屈曲后行为。基于文献中报道的尺寸和非线性各向异性材料特性，使用有限元分析对具有对称和非对称斑块的模型冠状动脉进行屈曲分析。与对称斑块和对照动脉相比，不对称斑块的动脉具有较低的临界屈曲压力。屈曲增加了斑块中的峰值应力，并导致不对称斑块动脉中的高应力集中。硬化组织和严重狭窄增加了不对称斑块动脉的临界屈曲压力。具有动脉粥样硬化斑块的动脉易于发生机械屈曲，这导致斑块中的高应力集中，这可能使斑块易于破裂。
Tortuous arteries are often seen in patients with hypertension and atherosclerosis. While the mechanical stress in atherosclerotic plaque under lumen pressure has been studied extensively, the mechanical stability of atherosclerotic arteries and subsequent effect on the plaque stress remain unknown. To this end, we investigated the buckling and post-buckling behavior of model stenotic coronary arteries with symmetric and asymmetric plaque. Buckling analysis for a model coronary artery with symmetric and asymmetric plaque was conducted using finite element analysis based on the dimensions and nonlinear anisotropic materials properties reported in the literature. Artery with asymmetric plaque had lower critical buckling pressure compared to the artery with symmetric plaque and control artery. Buckling increased the peak stress in the plaque and led to the development of a high stress concentration in artery with asymmetric plaque. Stiffer calcified tissue and severe stenosis increased the critical buckling pressure of the artery with asymmetric plaque. Arteries with atherosclerotic plaques are prone to mechanical buckling which leads to a high stress concentration in the plaques that can possibly make the plaques prone to rupture.