Eight-Step Total Synthesis of Phalarine by Bioinspired Oxidative Coupling of Indole and Phenol
Eight-Step Total Synthesis of Phalarine by Bioinspired Oxidative Coupling of Indole and Phenol
复制标题
吲哚与苯酚仿生氧化偶联八步全合成法拉林
DOI：
10.1002/anie.201900199
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Jia Yanxing
中科院分区：
文献类型：
--
作者：
Li Lei;Yuan Kuo;Jia Qianlan;Jia Yanxing
我们首次报道了苯并呋喃并[3，2-B]吲哚啉骨架可以通过PIDA介导的2，3-二取代吲哚与苯酚的直接氧化偶联得到。这种化学的应用允许从市售色胺八步全合成法拉林。
We report for the first time that the benzofuro[3,2‐b]indoline framework could be obtained by PIDA‐mediated direct oxidative coupling of 2,3‐disubstituted‐indoles with phenols. Application of this chemistry allows for an eight‐step total synthesis of phalarine from commercially available tryptamine.