Precision radiotherapy for small animal research.
Precision radiotherapy for small animal research.
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用于小动物研究的精准放射治疗。
DOI：
10.1007/978-3-540-85990-1_74
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Kazanzides,Peter
中科院分区：
文献类型：
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作者：
Matinfar,Mohammad;Iordachita,Iulian;Ford,Eric;Wong,John;Kazanzides,Peter
使用具有良好特征的小动物模型进行的临床前研究为医学研究提供了巨大的好处，使低成本、大规模试验成为可能，观察到的效果具有很高的统计意义。小动物辐射研究平台(SARRP)的目标是使这些模型可用于开发和评估新型放射疗法。SARRP展示了在机载锥束CT(CBCT)指导下提供高分辨率、亚毫米、最佳计划的共形辐射的能力。该系统需要对用于成像和放射治疗的X射线束进行精确校准。在本文中，我们提出了一种使用X射线相机来校准治疗光束的新技术。这项技术不需要精确定位或校准X射线相机。
Preclinical research using well characterized small animal models has provided tremendous benefits to medical research, enabling low cost, large scale trials with high statistical significance of observed effects. The goal of the Small Animal Radiation Research Platform (SARRP) is to make those models available for the development and evaluation of novel radiation therapies. SARRP demonstrates the capabilities of delivering high resolution, sub-millimeter, optimally planned conformal radiation with on-board cone-beam CT (CBCT) guidance. The system requires accurate calibration of the x-ray beam for both imaging and radiation treatment. In this paper, we present a novel technique using an x-ray camera for calibration of the treatment beam. This technique does not require precise positioning or calibration of the x-ray camera.