Inhibitory effect of metformin on intestinal glucose absorption in the perfused rat intestine
Inhibitory effect of metformin on intestinal glucose absorption in the perfused rat intestine
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DOI：
10.1016/s0006-2952(99)00396-2
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发表时间：
2000-04-01
影响因子：
5.8
通讯作者：
Murakami, H
中科院分区：
文献类型：
--
作者：
Ikeda, T;Iwata, K;Murakami, H
为了研究二甲双胍对大鼠肠道葡萄糖吸收的影响，进行了大鼠肠道的灌流实验。实验选用8周龄雄性Wistar白化大鼠。在灌流液(788.1+/-118.2 mU/L/30min)中直接加入90 mU/m L二甲双胍(90 mU/m L)或十二指肠内注入(772.8+/-105.3 mU/L生理盐水)二甲双胍(250 mg/kg生理盐水)对灌流肠葡萄糖吸收无明显影响。灌胃给药5天后，大鼠灌流肠对葡萄糖的吸收率(375.0±164.3µm o l/30min)显著低于对照组(811.0±83.1m o l/30min)(P<0.001)。这些结果表明，二甲双胍对大鼠的消化道有明显的影响，对大鼠的肠道葡萄糖吸收有抑制作用。Biochem Pharmacol 59；7：887-890,2000。(C)2000年爱思唯尔科学公司。
To investigate the effect of metformin on intestinal glucose absorption, a perfusion study of the intestine was performed in the rat. Male Wistar albino rats (8-weeks old) were used in the present study. The glucose absorption by the perfused intestine (788.1 +/- 81.9 mu mol/30 min) was not changed significantly by the direct addition of metformin (90 mu g/mL) to the perfusing medium (737.0 +/- 118.2 mu mol/30 min) or by intraduodenal metformin (250 mg/kg in saline solution) infusion (772.8 +/- 105.3 mu mol/30 min). In rats orally administered metformin (250 mg/kg) for 5 days, glucose absorption by the perfused intestine (375.0 +/- 164.3 mu mol/30 min) was significantly (P < 0.001) lower than that: in control rats (811.0 +/- 83.1 mu mol/30 min). These results indicate that metformin had a significant effect on the digestive tract, and that metformin treatment exerted an inhibitory effect on intestinal glucose absorption in the rat. BIOCHEM PHARMACOL 59;7:887-890, 2000. (C) 2000 Elsevier Science Inc.