Regulation of oral antigen delivery early in life: Implications for oral tolerance and food allergy.
Regulation of oral antigen delivery early in life: Implications for oral tolerance and food allergy.
复制标题
DOI：
10.1111/cea.13823
复制
发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Knoop KA
中科院分区：
文献类型：
--
作者：
Yokanovich LT;Newberry RD;Knoop KA
食物过敏的发病率不断增加，仍然是一个重大的公共卫生问题。食物过敏部分是由于缺乏或失去对食物过敏原的耐受性。围绕早期生活实践的临床结果，如母乳喂养，抗生素使用和食物过敏原暴露，表明儿童生命的第一年是塑造免疫系统以减少过敏结果的独特时间。动物模型已经确定了饮食抗原在肠道内何时何地递送以促进断奶前口服耐受性的独特方面。此外，动物模型已经确定了母乳中的母体蛋白质和肠道微生物群中的细菌产物在调节饮食抗原暴露和促进口服耐受性方面的贡献，从而将数十年的临床观察与母乳喂养，早期食物过敏原引入和抗生素避免的益处联系起来。在这里，我们讨论了如何暴露于肠腔抗原，包括食物过敏原，在生命早期进行调节，以产生保护性耐受性，以及这一过程对预防和治疗食物过敏的影响。
The increasing incidence of food allergy remains a significant public health concern. Food allergy is partially due to a lack, or loss of tolerance to food allergens. Clinical outcomes surrounding early life practices, such as breastfeeding, antibiotic use, and food allergen exposure, indicate the first year of life in children represents a unique time for shaping the immune system to reduce allergic outcomes. Animal models have identified distinctive aspects of when and where dietary antigens are delivered within the intestinal tract to promote oral tolerance prior to weaning. Additionally, animal models have identified contributions from maternal proteins from breastmilk and bacterial products from the gut microbiota in regulating dietary antigen exposure and promoting oral tolerance, thus connecting decades of clinical observations on the benefits of breastfeeding, early food allergen introduction, and antibiotic avoidance in the first year of life in reducing allergic outcomes. Here we discuss how exposure to gut luminal antigens, including food allergens, is regulated in early life to generate protective tolerance and the implications of this process for preventing and treating food allergies.
影响因子：
3.7
作者：
Stern A;Wold AE;Östman S
通讯作者：
Östman S