GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction
GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction
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DOI：
10.1093/ajcn/86.3.752
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发表时间：
2007-09-01
影响因子：
7.1
通讯作者：
Campos, Hannia
中科院分区：
文献类型：
--
作者：
Cornelis, Marilyn C.;El-Sohemy, Ahmed;Campos, Hannia
背景：十字花科蔬菜是异硫氰酸酯的主要膳食来源，可以预防冠心病。异硫氰酸盐诱导谷胱甘肽S-转移酶（GST），多态性基因编码的酶，共轭异硫氰酸盐，以及诱变剂和活性氧，使他们更容易exertable.Objective：本研究的目的是确定GST基因型是否修改十字花科蔬菜摄入量和心肌梗死（MI）的风险之间的关联。设计：首次急性非致死性心肌梗死病例（n = 2042）和居住在哥斯达黎加的人群对照（n = 2042），年龄、性别和居住地区相匹配，对GSTM 1和GSTT 1的缺失多态性和GSTP 1的Ile 105 Val取代进行基因分型。通过问卷调查确定十字花科蔬菜摄入量和吸烟状况。结果：与十字花科蔬菜摄入量最低的三分位数相比，功能性GSTT 1 *1等位基因的最高三分位数与MI风险降低相关（OR：0.70; 95% CI：0.58，0.84），但在GSTT 1 *0*0基因型之间无显著性差异（OR：1.23; 95% CI：0.83，1.82）（交互作用P = 0.006）。与非吸烟者相比，目前吸烟者携带GSTT 1 *1等位基因的保护作用更大（OR：0.54; 95%CI：0.36，0.79）。GSTP 1和GSTM 1没有修改十字花科蔬菜摄入量和MI之间的关联。结论：十字花科蔬菜的消费与MI的风险较低的功能性GSTT 1 *1等位基因，这表明该酶的解毒化合物的MI的风险。
Background: Cruciferous vegetables are a major dietary source of isothiocyanates that may protect against coronary heart disease. Isothiocyanates induce glutathione S-transferases (GSTs), polymorphic genes that code for enzymes that conjugate isothiocyanates, as well as mutagens and reactive oxygen species, to make them more readily excretable.Objective: The objective of the study was to determine whether GST genotypes modify the association between cruciferous vegetable intake and the risk of myocardial infarction (MI).Design: Cases (n = 2042) with a first acute nonfatal MI and population-based controls (n = 2042) living in Costa Rica, who were matched for age, sex, and area of residence, were genotyped for a deletion polymorphism in GSTM1 and GSTT1 and an Ile105Val substitution in GSTP1. Cruciferous vegetable intake and smoking status were determined by questionnaire. Odds ratios (ORs) and 95% Cls for MI were estimated by unconditional logistic regression.Results: Compared with the lowest tertile of cruciferous vegetable intake, the highest tertile was associated with a lower risk of MI among persons with the functional GSTT1 *1 allele (OR: 0.70; 95% Cl: 0.58, 0.84) but not among those with the GSTT1*0*0 genotype (OR: 1.23; 95% Cl: 0.83, 1.82) (P = 0.006 for interaction). This protective effect among those with the GSTT1*1 allele was greater for current smokers (OR: 0.54; 95% Cl: 0.36, 0.79) than for nonsmokers. GSTP1 and GSTM1 did not modify the association between cruciferous vegetable intake and MI.Conclusions: Consumption of cruciferous vegetables was associated with a lower risk of MI among those with a functional GSTT1*1 allele, which suggests that compounds that are detoxified by this enzyme contribute to the risk of MI.