The expression of ERCC1, RRM1, and BRCA1 in breast cancer according to the immunohistochemical phenotypes.
The expression of ERCC1, RRM1, and BRCA1 in breast cancer according to the immunohistochemical phenotypes.
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DOI：
10.3346/jkms.2011.26.3.352
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发表时间：
2011-03
影响因子：
4.5
通讯作者：
Koo JS
中科院分区：
文献类型：
--
作者：
Kim D;Jung W;Koo JS
我们研究了BRCA 1、ERCC 1和RRM 1在乳腺癌中的表达，它们在DNA修复系统中起重要作用。采用组织芯片对230例乳腺癌患者进行EGFR、BRCA 1、ERCC 1和RRM 1的免疫组化染色。根据ER、PR和HER-2表达将患者分为管腔A型、管腔B型、HER-2型和三阴性乳腺癌（TNBC）型。ERCC 1、RRM 1和BRCA 1的表达呈相关性（P < 0.05）。ERCC 1在TNBC型中表达最低（P = 0.031），在TNBC和Luminal B组中ERCC 1的阴性表达明显高于Luminal A和HER-2组（P = 0.013）。EGFR过表达的病例中RRM 1和BRCA 1表达增高（P分别为0.046和0.004）。总之，ERCC 1的表达在TNBC中比其他类型的乳腺癌特别低。
We studied the expression of BRCA1, ERCC1, and RRM1 which play an important role in DNA repair systems in breast cancer. Immunohistochemical staining for EGFR, BRCA1, ERCC1, and RRM1 were performed by using a tissue microarray made from 230 breast cancer patients. Patients were classified into luminal A, luminal B, HER-2, and triple negative breast cancer (TNBC) types according to ER, PR, and HER-2 expression. The expression of ERCC1, RRM1, and BRCA1 were correlated (P < 0.05). The expression level of ERCC1 was the lowest in TNBC type (P = 0.031), ERCC1 negativity was more prominent in TNBC and luminal B groups than luminal A and HER-2 groups (P = 0.013). Cases with EGFR overexpression showed high expression of RRM1 and BRCA1 (P = 0.046, and 0.004, respectively). In conclusion, the expression of ERCC1 is particularly lower in TNBCs than other types of breast cancers.
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影响因子：
56.9
作者：
FUTREAL, PA;LIU, QY;WISEMAN, R
通讯作者：
WISEMAN, R
影响因子：
--
作者：
Zdraveski, ZZ;Mello, JA;Essigmann, JM
通讯作者：
Essigmann, JM
影响因子：
3.3
作者：
Rakha, Emad A.;El-Sheikh, Sornaia E.;Ellis, Ian O.
通讯作者：
Ellis, Ian O.
影响因子：
4.8
作者：
Bhattacharyya, A;Ear, US;Bishop, DK
通讯作者：
Bishop, DK
影响因子：
45.3
作者：
Metzger, R;Leichman, CG;Leichman, L
通讯作者：
Leichman, L