Length dependence of changes in sarcoplasmic calcium concentration and myofibrillar calcium sensitivity in striated muscle fibres
Length dependence of changes in sarcoplasmic calcium concentration and myofibrillar calcium sensitivity in striated muscle fibres
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横纹肌纤维肌浆钙浓度和肌原纤维钙敏感性变化的长度依赖性
DOI：
10.1007/bf00713107
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发表时间：
1984
影响因子：
2.7
通讯作者：
I. Wendt
中科院分区：
文献类型：
--
作者：
D. Stephenson;I. Wendt
早已知道横纹肌的收缩性能强烈地依赖于肌肉的长度（例如Ramsey & Street，1940），并且肌肉收缩的滑动细丝理论提供了对完全激活的骨骼肌纤维的等距长度-力关系的许多特征的现成解释（Gordon等人，1966年b）。然而，在过去的十年中，它已经变得越来越明显，在不同长度的横纹肌的机械行为的差异，特别是如果次最大限度地激活，往往不能令人满意地解释的基础上，单独的细丝重叠。越来越多的证据表明，改变肌纤维的长度不仅会改变细丝的物理重叠（即条纹间距或肌节长度），而且还会改变参与收缩激活的其他过程。特别是它出现的肌浆Ca 2+浓度的变化，这发生在兴奋的纤维，和明显的敏感性的收缩蛋白质Ca 2+可以随肌肉长度的特性。本文将主要关注收缩激活的这两个方面的长度依赖性。
It has long been known that the contractile performance of striated muscle is strongly dependent upon the length of the muscle (e.g. Ramsey & Street, 1940) and the sliding filament theory of muscle contraction offers a ready explanation for many features of the isometric length-force relation of fully activated skeletal muscle fibres (Gordon et al., 1966b). Over the past decade, however, it has become increasingly more apparent that differences in the mechanical behaviour of striated muscle at different lengths, particularly if submaximally activated, often cannot be satisfactorily explained on the basis of filament overlap alone. There is growing evidence that changing the length of a muscle fibre alters not only the physical overlap of the filaments (i.e. the striation spacing or sarcomere length) but also modifies other processes involved in the activation of contraction. In particular it appears that both the characteristics of the sarcoplasmic Ca 2+ concentration change, which occurs upon excitation of the fibre, and the apparent sensitivity of the contractile proteins to Ca 2+ can vary with muscle length. This article will concern itself principally with the length dependence of these two aspects of contractile activation.
猫乳头肌中的细胞内 Ca2 瞬变。
影响因子：
2.1
作者：
Morgan,JP;Blinks,JR
通讯作者：
Blinks,JR
影响因子：
5.5
作者：
ALLEN, DG;KURIHARA, S
通讯作者：
KURIHARA, S