Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis
Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis
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DOI：
10.1111/jvim.15492
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发表时间：
2019-05-01
影响因子：
2.6
通讯作者：
Fukata, Masaki
中科院分区：
文献类型：
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作者：
Hasegawa, Daisuke;Ohnishi, Yumi;Fukata, Masaki
一只7岁的雌性家养短毛猫出生于波兰，后来移居日本，最近出现痉挛丛集性发作和癫痫持续状态，并在当地诊所就诊。磁共振成像显示双侧海马区肿胀，呈T2高信号和增强像，提示海马区坏死。经抗癫痫药物(AED)治疗和强的松龙(1 mg/kg PO，q24，4d，逐渐减少)治疗后，猫完全恢复。然而，尽管增加了AED的剂量，丛集性发作再次发生并发展为癫痫持续状态。虽然惊厥被其他抗癫痫药物消除，但出现了昏迷和肾功能衰竭，猫被安乐死。病理结果与海马区坏死相一致。免疫分析富亮氨酸胶质瘤灭活1(LGI1)自身抗体为阴性，但发现抗体DCC(在结直肠癌中缺失)被称为Netrin-1受体。本报告描述了一例猫自身免疫性边缘脑炎和海马区坏死，推测与DCC自身抗体有关。
A 7-year-old neutered female domestic shorthaired cat born in Poland and then moved to Japan presented to the local clinic with recent onset of convulsive cluster seizures and status epilepticus. Magnetic resonance imaging revealed bilateral swelling of the hippocampus with T2 hyperintensity and contrast enhancing image, suggesting hippocampal necrosis. The cat completely recovered after treatment with antiepileptic drugs (AED) and administration of prednisolone (1 mg/kg PO q24h for 4 days and tapered). However, cluster seizures reoccurred and developed into status epilepticus despite increasing doses of AED. Although the convulsions were resolved by other AEDs, stupor and renal failure developed, and the cat was euthanized. Pathological findings were consistent with hippocampal necrosis. Immunological analysis for leucine-rich glioma inactivated 1 (LGI1) autoantibodies was negative, but antibodies against DCC (deleted in colorectal carcinoma) known as netrin-1 receptor were found. This report describes a case of feline autoimmune limbic encephalitis and hippocampal necrosis that were presumably associated with DCC autoantibodies.