Transition-Metal-Free Alkynylation of 2-Oxindoles through Radical-Radical Coupling
Transition-Metal-Free Alkynylation of 2-Oxindoles through Radical-Radical Coupling
复制标题
通过自由基-自由基偶联对 2-羟吲哚进行无过渡金属的炔基化
DOI：
10.1021/acs.joc.6b03057
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发表时间：
2017-03-03
影响因子：
3.6
通讯作者：
Li, Chao-Jun
中科院分区：
文献类型：
--
作者：
Huang, Hong-Yan;Cheng, Liang;Li, Chao-Jun
提出了一种有效的自由基偶联合成3-炔基-2-氧吲哚的无过渡金属方法。该反应对2-氧吲哚和碘代炔类化合物是普遍的，并以良好到极好的产率提供了在C3上带有四元中心的所需产物，使得该方法在合成螺环和稠合2-氧吲哚衍生物方面具有可行性和吸引力。
An effective transition-metal-free approach for the synthesis of 3-alkynyl-2-oxindoles through a radical radical coupling process was developed. The reaction was general with respect to 2-oxindoles and iodoalkynes and provided the desired products bearing a quaternary center at C3 in good to excellent yields, making this method synthetically viable and attractive for the synthesis of spiro and fused 2-oxindole derivatives.