REGULATION OF FOOD AND WATER INTAKE IN RATS AS RELATED TO PLASMA OSMOLARITY AND VOLUME
REGULATION OF FOOD AND WATER INTAKE IN RATS AS RELATED TO PLASMA OSMOLARITY AND VOLUME
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DOI：
10.1016/0031-9384(69)90181-4
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发表时间：
1969-01-01
影响因子：
2.9
通讯作者：
KRAUSZ, M
中科院分区：
文献类型：
--
作者：
GUTMAN, Y;KRAUSZ, M
皮下注射高渗生理盐水可抑制大鼠的进食，而腹腔注射等渗生理盐水可增加大鼠的进食。皮下注射聚乙二醇（Carbowax, M-20）引起的低血容量可显著减少大鼠的食物摄取量。在没有食物的情况下自由饮水导致血浆明显稀释，而在没有水的情况下自由饮水导致血浆高渗。23小时进食+ 1小时饮水vs 23小时饮水+ 1小时进食，血浆渗透压从286 mOsm/kg变化到318 mOsm/kg。这些广泛的变化讨论了血浆渗透压与食物和水摄入的相互作用。
Food intake was suppressed in rats by subcutaneous injection of hypertonic saline while intraperitoneal loading of isotonic saline increased food consumption. Hypovolemia induced by subcutaneous injection of polyethylene glycol (Carbowax, M-20), decreased food intake in rats considerably. Free access to water under food deprivation caused significant dilution of plasma while free access to food under water deprivation resulted in hypertonicity of plasma. Feeding schedules of 23 hr food and 1 hr water vs 23 hr water and 1 hr food, caused plasma osmolarity to change from 286 mOsm/kg to 318 mOsm/kg. These wide variations are discussed in relation to the interaction of plasma osmolarity with food and water intake.