Reversal of Organophosphorus‐induced Depression of the Monosynaptic Reflex in Spinal Cords of Neonatal Rats by Thyrotropin‐Releasing Hormone a
Reversal of Organophosphorus‐induced Depression of the Monosynaptic Reflex in Spinal Cords of Neonatal Rats by Thyrotropin‐Releasing Hormone a
复制标题
促甲状腺激素释放激素 a 逆转有机磷诱导的新生大鼠脊髓单突触反射抑制
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
J. E. Warnick
中科院分区：
文献类型：
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作者：
S. Gupta;S. Deshpande;J. E. Warnick
有机磷（OP）类药物如二异丙基氟磷酸盐（DFP）和沙林（sarin）能促进和/或抑制猫（1 S2）和新生大鼠脊髓（3）的单突触反射（MSR），其作用方式与乙酰胆碱酯酶活性无关。沙林和DFP在新生大鼠脊髓中的毒性作用可被抗毒蕈碱剂（如阿托品和哌仑西平）逆转或预防，但不能被烟碱阻断剂d-筒箭毒碱和美加明逆转或预防（个人观察）。促甲状腺激素释放激素（TRH）可以逆转各种中枢神经系统抑制剂（如肾上腺素）的镇静作用。巴比土酸盐和乙醇14 p5），其作用与中枢胆碱能位点密切相关。6因此，我们检测了TRH逆转OP诱导的MSR抑制的能力。
Organophosphorus (OP) agents such as diisopropylphosphorofluoridate (DFP) and sarin can facilitate and/or depress the monosynaptic reflex (MSR) in cats,lS2 in viva, and in the neonatal rat spinal cord,3 in vitra, in a manner unrelated to the activity of acetylcholinesterase. The depressant effects of sarin and DFP in the neonatal rat cord are reversed or prevented by antimuscarinic agents, such as atropine and pirenzepine, but not by the nicotinic blocking agents d-tubocurarine and mecamylamine (personal observations). Thyrotropin-releasing hormone (TRH) can reverse the sedative effects of various central nervous system depressants (e .g . barbiturates and ethano14p5), and its actions have been closely associated with central cholinergic sites.6 We therefore examined the ability of TRH to reverse OP-induced depression of the MSR.