Critical care aspects of malaria.
Critical care aspects of malaria.
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DOI：
10.1177/0885066609356052
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发表时间：
2010-03-01
影响因子：
3.1
通讯作者：
Talwar, Arunabh
中科院分区：
文献类型：
--
作者：
Sarkar, Pralay K;Ahluwalia, Gautam;Talwar, Arunabh
疟疾仍然是亚洲和非洲大部分地区的一个主要健康问题。在发达世界的许多国家，输入性疟疾病例也在稳步增加。恶性疟原虫疟疾以及在某种程度上由其他疟原虫引起的疟疾可导致许多并发症，例如急性呼吸窘迫综合征（ARDS）、脑型疟疾、急性肾衰竭、严重贫血、血小板减少和出血并发症。大约10%的严重疟疾患者死亡，通常是由于多器官功能障碍。重症监护医生应了解重症疟疾的并发症和管理。在过去十年中，对重症疟疾发病机制的认识取得了重大进展。重症疟疾的有效管理包括早期怀疑、及时诊断、早期建立适当的抗疟化疗和支持性护理，最好是在重症监护室。在这篇文章中，我们回顾了重症疟疾的不同表现，并讨论了实验室诊断和管理的原则。
Malaria remains a major health problem in much of Asia and Africa. A steady number of cases of imported malaria are also seen in many countries of the developed world. Plasmodium falciparum malaria and to some extent malaria caused by other species of Plasmodium can lead to many complications such as acute respiratory distress syndrome (ARDS), cerebral malaria, acute renal failure, severe anemia, thrombocytopenia, and bleeding complications. About 10% of patients with severe malaria die, usually as a result of multiorgan dysfunction. Critical care physicians should be aware of the complications and management of severe malaria. There has been significant progress in the understanding of pathogenesis of severe malaria over the last decade. Effective management of severe malaria includes early suspicion, prompt diagnosis, early institution of appropriate antimalarial chemotherapy, and supportive care, preferably in an intensive care unit. In this article, we review the different manifestations of severe malaria as relevant to critical care physicians and discuss the principles of laboratory diagnosis and management.