Altered white matter in early visual pathways of humans with amblyopia
Altered white matter in early visual pathways of humans with amblyopia
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DOI：
10.1016/j.visres.2014.12.021
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发表时间：
2015-09-01
期刊：
影响因子：
1.8
通讯作者：
Rokers, Bas
中科院分区：
文献类型：
--
作者：
Allen, Brian;Spiegel, Daniel P.;Rokers, Bas
弱视是一种由于发育过程中双眼输入不协调而导致的视觉障碍。弱视对视觉系统内白质的影响知之甚少。我们用弥散加权成像(DWI)和纤维束成像技术研究了一组成人弱视患者(n=10)和10例正常对照(n=10)的6条主要视觉白质通路的特性。虽然我们没有发现皮质-皮质通路的弥散特性有显著差异，但弱视患者丘脑-皮质视觉通路的平均弥散系数增加。这些发现表明，弱视可能会系统性地改变早期视觉通路的白质特性。(C)2015爱思唯尔有限公司。保留所有权利。
Amblyopia is a visual disorder caused by poorly coordinated binocular input during development. Little is known about the impact of amblyopia on the white matter within the visual system. We studied the properties of six major visual white-matter pathways in a group of adults with amblyopia (n = 10) and matched controls (n = 10) using diffusion weighted imaging (DWI) and fiber tractography. While we did not find significant differences in diffusion properties in cortico-cortical pathways, patients with amblyopia exhibited increased mean diffusivity in thalamo-cortical visual pathways. These findings suggest that amblyopia may systematically alter the white matter properties of early visual pathways. (C) 2015 Elsevier Ltd. All rights reserved.