ACUTE EFFECTS OF OVARIECTOMY ON PITUITARY LH UTERINE WEIGHT + VAGINAL CORNIFICATION
ACUTE EFFECTS OF OVARIECTOMY ON PITUITARY LH UTERINE WEIGHT + VAGINAL CORNIFICATION
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DOI：
10.1152/ajplegacy.1964.207.6.1251
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发表时间：
1964-01-01
影响因子：
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通讯作者：
SCHWARTZ, NB
中科院分区：
文献类型：
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作者：
SCHWARTZ, NB
在周期性大鼠中，子宫重量在发情前期增加，垂体LH含量从发情前期的最大值下降到发情期的最小值，然后发生排卵和阴道角化。为了研究可能导致这些变化的卵巢分泌的时间，在发情前一天以增加的间隔进行卵巢切除术或假卵巢切除术。在4天和5天周期中的结果表明，卵巢必须在发情间期4 PM（发情前期前一天）和发情前期10 AM之间原位，以发生发情阴道角化;它必须在发情间期10 AM和4 PM（发情前期前一天）之间原位，以发生子宫重量增加和垂体LH分泌。在一些大鼠假卵巢切除术，在动情间期10上午进行时，延迟了至少24小时的前动情期-动情期的变化。“额外”的一天，发生在正常的5天周期的结果，至少部分从延迟类固醇的排放，必要的，以引起释放排卵激增的LH。
In the cyclic rat, uterine weight increases at proestrus, pituitary LH content drops from a maximum at proestrus to a minimum at estrus, and ovulation and vaginal cornification then occur. To investigate the timing of the ovarian secretion presumably responsible for these changes, ovariectomy or sham ovariectomy was performed at increasing intervals before the day of estrus. Results in both 4- and 5-day cyclers indicate that the ovary must be in situ between diestrus 4 PM (day before proestrus) and proestrus 10 AM in order for estrous vaginal cornification to occur; it must be in situ between diestrus 10 AM and 4 PM (day before proestrus) for the uterine weight increase and pituitary LH discharge to occur. In some rats sham ovariectomy, when performed at diestrus 10 AM, delayed the proestrous-estrous changes by at least 24 hr. The "extra" day which occurs in normal 5-day cycles results at least partly from a delay in the steroid discharge necessary to cause release of the ovulating surge of LH.