Stress inhibits PYY secretion in obese and normal weight women
Stress inhibits PYY secretion in obese and normal weight women
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DOI：
10.1007/s40519-015-0231-y
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发表时间：
2016-06-01
影响因子：
2.9
通讯作者：
Laessle, Reinhold G.
中科院分区：
文献类型：
--
作者：
Kiessl, Gundula R. R.;Laessle, Reinhold G.
压力对食欲调节激素循环水平的影响在很大程度上仍然未知。本研究的目的是分析急性心理社会应激对肥胖和正常体重女性肠道激素肽YY（PYY）分泌的影响。因此，我们在一项重复测量的随机对照实验室实验中比较了42名肥胖和43名正常体重妇女餐前和餐后血浆PYY的分泌。测量PYY和皮质醇浓度，并记录对心理应激源（特里尔社会应激试验，TSST）的应激和饱腹感评分。在参与TSST之前和对照阶段之前，在空腹状态下采集PYY样本。参与者在TSST和对照会议后分别吃了标准餐。分别在TSST和对照期后30和60 min测量PYY。在所有女性中，压力抑制PYY分泌以及食物摄入，但不影响主观饱腹感。目前的数据表明，尽管PYY水平较低，但受试者对暴饮暴食的需求并未增加。从进化的角度来看，这一发现是适应性的。在应激后，机体准备好进行战斗或逃跑反应，而不是主要必要的功能被抑制。因此，在压力下增加食物摄入量将是功能失调的。
The impact of stress on circulating levels of appetite-regulating hormones remains largely unknown. The aim of this study was to analyze the effect of acute psychosocial stress on the gut hormone peptide YY (PYY) secretion in obese and normal weight women. Therefore, we compared pre- and post-prandial plasma PYY secretion of 42 obese and 43 normal weight women in a repeated measure randomized controlled laboratory experiment. PYY and cortisol concentrations were measured and ratings of stress and satiety were also recorded in response to a psychological stressor (Trier Social Stress Test, TSST). PYY samples were collected in the fasting state both before participating in the TSST and before a control session. Participants had a standardized meal after the TSST and control session, respectively. PYY was measured both 30 and 60 min after the TSST and control session, respectively. Stress inhibited PYY secretion as well as food intake in all women, but did not influence subjective satiety perception. The present data indicate that despite of lower PYY levels the subjects' requirement to overeat was not increased. From an evolutionary perspective this finding is adaptive. After stress the organism is prepared for fight or flight reaction, whereas not primarily necessary functions are inhibited. Therefore, increased food intake during stress would be dysfunctional.