Drug Allergy: An Updated Practice Parameter
Drug Allergy: An Updated Practice Parameter
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DOI：
10.1016/j.anai.2010.08.002
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发表时间：
2010-10-01
影响因子：
5.9
通讯作者：
Schwartz, Lawrence B.
中科院分区：
文献类型：
--
作者：
Solensky, Roland;Khan, David A.;Schwartz, Lawrence B.
药物不良反应（adr）导致主要的健康问题在美国的住院和门诊设置。adr大致分为可预测（A型）反应和不可预测（B型）反应。可预测的反应通常是剂量依赖性的，与药物的已知药理作用有关，并且发生在健康个体中，据估计，这些反应约占所有adr的80%。不可预测通常与剂量无关，与药物的药理作用无关，只发生在易感个体中。不可预测的反应又分为药物不耐受、药物特异性、药物过敏和假过敏反应。A型和B型反应都可能受到患者遗传易感性的影响
Adverse drug reactions (ADRs) result in major health problems in the United States in both the inpatient and outpatient setting. ADRs are broadly categorized into predictable (type A and unpredictable (type B) reactions. Predictable reactions are usually dose dependent, are related to the known pharmacologic actions of the drug, and occur in otherwise healthy individuals, They are estimated to comprise approximately 80% of all ADRs. Unpredictable are generally dose independent, are unrelated to the pharmacologic actions of the drug, and occur only in susceptible individuals. Unpredictable reactions are subdivided into drug intolerance, drug idiosyncrasy, drug allergy, and pseudoallergic reactions. Both type A and B reactions may be influenced by genetic predisposition of the patient